Noopept
Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)
An extremely potent nootropic peptide that enhances memory, learning, and neuroprotection at very low doses.
Noopept is a synthetic nootropic peptide developed in Russia that is estimated to be 1000 times more potent than piracetam by weight. Despite being called a racetam by some, it has a different structure (dipeptide). It rapidly crosses the blood-brain barrier and increases NGF and BDNF, supporting neuroplasticity and neuroprotection. Effects include improved memory consolidation, learning, and a mild psychostimulant effect.
Mechanisms of Action
NGF & BDNF Enhancement
Increases growth factors
AMPA/NMDA Sensitization
Enhances glutamate signaling
Neuroprotection
Protects neurons from damage
Recommended Dose
10-30mg daily in divided doses
Loading: Not required; start at 10mg
Optimal Timing
- Morning and early afternoon
- Divided into 2-3 doses
- Sublingual for faster onset
Can be taken without food
Best Form
Noopept powder (sublingual) or capsules
Alternatives: Noopept nasal spray
Powder for sublingual use offers faster absorption. Extremely potent - milligram scale needed for powder.
Duration
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: 8-12 weeks on, 4 weeks off
Note: Very potent - accurate dosing crucial. Sublingual absorption is faster. Avoid evening doses due to mild stimulation.
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Memory & Learning
Enhanced memory consolidation and learning
Mental Clarity
Improved focus and clarity of thought
Neuroprotection
Long-term brain health support
Irritability
Can cause irritability in some users
Popular for studying and cognitive enhancement
Who Should NOT Take This
- Severe hypertension
- Kidney or liver impairment
Possible Side Effects
Tip: Reduce dose
Tip: Add choline source
Tip: Avoid late doses
Warnings
- Extremely potent - accurate dosing is crucial
- Not FDA-approved in US
- Limited long-term human safety data
Top studies from 14+ peer-reviewed papers
Gudasheva TA et al. • Current pharmaceutical design (2018)
“The paper discusses the process, based on the abovementioned principles, that was used in designing of nontoxic, orally available, highly effective dipeptide drugs: nootropic noopept, dipeptide analog of piracetam; antipsychotic dilept, neurotensin tripeptoid analog; selective anxiolytic GB-115, tripeptoid analog of CCK-4, and potential neuroprotector GK-2, homodimeric dipeptide analog of NGF.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.”
Key Findings:
- The latter usually corresponds to a beta-turn of some regulatory peptide.
- The second approach represents the design of tripeptoide mimetic of the beta-turn of regulatory peptide or protein.
- The results of the studies, which led to the discovery of endogenous prototypes of the known non-peptide drugs piracetam and sulpiride, are presented herein.
Ostrovskaya RU et al. • Journal of biomedical science (2014)
“Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.”
Key Findings:
- Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.
- Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells.
- Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying Aβ-related pathology.
Neznamov GG et al. • Neuroscience and behavioral physiology (2009)
“This observational examined the effects of Noopept.”
Key Findings:
- Clinical trial examining Noopept efficacy
- Published in Neuroscience and behavioral physiology (2009)
- Further research warranted to confirm findings
Zainullina LF et al. • Doklady. Biochemistry and biophysics (2020)
“It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.”
Key Findings:
- The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
- Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
- The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.
- It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.
Zainullina LF et al. • Bulletin of experimental biology and medicine (2019)
“These data suggest that Noopept does not stimulate cell growth.”
Key Findings:
- The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity.
- The possible mitogenic action of Noopept was estimated by its effect on cell proliferation.
- Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study.
- These data suggest that Noopept does not stimulate cell growth.
Study Type Distribution
Goals This Supplement Supports
Related Goals
This information is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before starting any supplement.