Find supplements that actually work
Most supplement sites want to sell you something. SupStack just helps you figure out what's backed by real research — and what's not worth your money.
How it works
From research to results in four steps
Pick your goals
Sleep, focus, recovery, energy — whatever you're trying to improve.
See what works
Get supplements ranked by how strong the research actually is.
Build your stack
Save your selections and share your stack with friends or doctors.
Run experiments
Track your personal response with N-of-1 experiments and get a verdict.
Test what actually works for you
Research tells you what works on average. N-of-1 experiments tell you what works for you.
Creatine for Focus & Cognition
30-day trial • 5g daily • 4 check-ins
Focus scores improved from 5/10 to 7.5/10. Working memory tasks felt noticeably easier by week 3.
What makes SupStack different
Research, not marketing
Every supplement is rated based on actual clinical studies — not influencer posts or manufacturer claims.
Sources you can check
Every rating links back to PubMed studies. Don't take our word for it — read the research yourself.
Safety info upfront
Drug interactions, side effects, and who should avoid what — the stuff that's usually buried in fine print.
Continuously validated
Every claim is cross-checked against real studies. Scores and safety ratings get updated as new research comes out.
Strongest evidence
Supplements with the most solid research behind them
Caffeine
The world's most widely used stimulant, with strong evidence for enhancing alertness, focus, and physical performance.
Creatine
The most researched supplement for strength, power, and cognitive function under stress.
Acetyl-L-Carnitine
Brain-boosting form of carnitine that crosses the blood-brain barrier, supporting mental energy, focus, and neuroprotection.
Aged Garlic Extract
Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
Alpha Lipoic Acid
Universal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
Arginine
An amino acid precursor to nitric oxide that supports blood flow, exercise performance, and cardiovascular health.
Latest Research
Recently discovered studies across the supplement library
Does Nutrition Intervention Prevent and Heal Pressure Injury? A Systematic Review of Randomized Controlled Trials
Yildirim D et al. • Advances in skin & wound care (2026)
Across 18 studies including 1231 participants (aged 38 to 83 y) with stage 2 to 4 PIs, nutritional interventions demonstrated positive effects on prevention and healing.
- Across 18 studies including 1231 participants (aged 38 to 83 y) with stage 2 to 4 PIs, nutritional interventions demonstrated positive effects on prevention and healing.
- Formulas enriched with protein, arginine, zinc, antioxidants, and other nutrients appear promising; nonetheless, further large-scale, high-quality RCTs are needed to confirm these findings.
- Further research warranted to confirm findings
Efficacy and mechanisms of Xiangsha Liujunzi Decoction for gastroesophageal reflux disease: A study integrating meta-analysis, network pharmacology and molecular docking
Tian M et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.
- Eight RCTs (n = 646) showed that XSLJZD significantly improved clinical outcomes compared with controls, demonstrating superior overall efficacy and reduced recurrence.
- XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.
- The proposed anti-inflammatory and apoptotic mechanisms are computationally derived.
Caffeine and IBD Risk: A Meta-Analysis
Wu X et al. • Journal of gastroenterology and hepatology (2026)
The relationship between caffeine intake and IBD risk varies by region, age, caffeine source, smoking, and education level.
- The meta-analysis showed no significant association between caffeine intake and IBD (RR = 0.84, 95% CI = 0.68-1.04).
- In Americans, caffeine increased UC risk by 68% (RR = 1.68, 95% CI = 1.17-2.42).
- Age analysis showed caffeine increased IBD risk by 4.52 times in those ≤18 (RR = 4.52, 95% CI = 1.59-12.88) but decreased risk by 7% in those >18 (RR = 0.93, 95% CI = 0.73-1.18).
Efficacy and safety of boron neutron capture therapy for locally recurrent head and neck cancer
Sun X et al. • Critical reviews in oncology/hematology (2026)
BNCT has shown favorable efficacy and safety in LRHNC.
- The ORR was 70 % (95 % CI: 65 %-75 %; P = 0.8187) and the 2-year OS rate was 45 % (95 % CI: 39 %-50 %; P < 0.0001).
- The ORR of patients with non-squamous cell carcinoma (NSCC) was higher than those with squamous cell carcinoma (SCC) (82 % vs. 72 %), while the 2-year OS rates were similar (50 % vs. 49 %).
- The most frequent acute AEs included hyperamylasemia (75 %, 95 % CI: 70 %-80 %), alopecia (61 %, 95 % CI: 55 %-67 %), and submandibular gland inflammation (61 %, 95 % CI: 49 %-72 %).
Stop guessing. Start with the research.
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