DGL Licorice
Deglycyrrhizinated Licorice
Licorice root with the problematic compound removed, supporting gut lining healing and digestive comfort without affecting blood pressure.
DGL (Deglycyrrhizinated Licorice) is licorice root with glycyrrhizin removed — the compound that can raise blood pressure and cause potassium loss. What remains supports the gut lining, promotes mucus production, and has mild anti-inflammatory effects. Used for heartburn, ulcers, and gut healing. A safer alternative to regular licorice.
Mechanisms of Action
Mucus Production
Stimulates protective mucus secretion
Mucosal Healing
Supports gut lining repair
Recommended Dose
380-760mg, 2-4 times daily
Optimal Timing
- Before meals
- Chewable tablets for reflux
Can be taken without food
Best Form
Chewable tablets (for GERD/reflux)
Alternatives: Capsules, Powder
Chewing allows DGL to coat the esophagus and stomach directly. For capsules, open and mix with water for similar effect.
Duration
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Take 20-30 minutes before meals or between meals. Chewable form allows direct contact with esophagus for reflux.
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Heartburn Relief
Reduced acid reflux symptoms
Gut Soothing
Reduced digestive discomfort
DGL form is generally considered safe
DGL is safe — glycyrrhizin removed
Who Should NOT Take This
- Known allergy or hypersensitivity to DGL Licorice or related compounds
- Severe hypertension (even DGL form should be used cautiously)
Drug Interactions
DGL is much safer than regular licorice
Possible Side Effects
Tip: Reduce dose
Warnings
- Make sure it's DGL (deglycyrrhizinated) — NOT regular licorice
- Regular licorice can cause serious blood pressure and potassium issues
Top studies from 17+ peer-reviewed papers
Shi C et al. • Journal of biomaterials science. Polymer edition (2015)
“As there are still some problems with the development of DGL, further research is warranted for its broad applications.”
Key Findings:
- Another major class of synthetic polymers is dendrimers (after linear, cross-linked, and branched polymers).
- As there are still some problems with the development of DGL, further research is warranted for its broad applications.
- Further research warranted to confirm findings
da Rocha CMM et al. • Nutrients (2022)
“Conclusions: Among NW adolescents, GL is a better measure of carbohydrate quality, but for those with overweight/obesity, carbohydrate consumption is more associated with GC, probably because they eat/report small amounts of carbohydrates.”
Key Findings:
- Results: Of 35,737 students, 74% were from public schools, 60% girls, 17% overweight, and 8% obese.
- Glycosylated hemoglobin was not associated with these metrics, except for AvGL.
- Insulin and HOMA-IR were associated with all metrics in NW adolescents, with greater coefficients associated with AvGL.
- Among overweight/obese adolescents, only GI metrics were associated (β = 0.23; AvGI and insulin) and appeared to have the best association with GCM.
Rabe E et al. • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (2021)
“This systematic-review examined the effects of DGL Licorice.”
Key Findings:
- Systematic review examining DGL Licorice efficacy
- Published in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (2021)
- Further research warranted to confirm findings
Gu A et al. • The Journal of arthroplasty (2019)
“There is strong evidence that serologic malnutrition was associated with increased risk of poor postoperative outcome across all total joint replacement interventions.”
Key Findings:
- Eleven (55%) studies used the total lymphocyte count, and 6 (30%) studies reported transferrin as a marker for malnutrition.
- Among 20 studies, 18 (90%) studies reported a correlation with at least one serological marker and poor postoperative outcomes.
- Finally, patients with an albumin level <3.5 dg/L were more likely to develop a postoperative wound complication (odds ratio: 2.176; 95% confidence interval: 1.916-2.471).
Wolf J et al. • Gastroenterology (2017)
“In a prospective study, we validated the TTG-IgA procedure and the TTG-DGL procedure in identification of pediatric patients with or without celiac disease, without biopsy.”
Key Findings:
- Based on our extrapolation model, we estimated that the PPV and NPV would remain >0.95 even at a disease prevalence as low as 4%.
- Tests for endomysium antibodies and HLA type did not increase the PPV of samples with levels of IgA-TTG ≥10-fold the ULN.
- Notably, 4.2% of pathologists disagreed in their analyses of duodenal morphology-a rate comparable to the error rate for serologic assays.
Study Type Distribution
Goals This Supplement Supports
This information is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before starting any supplement.