Luteolin Research
50 peer-reviewed studies · Evidence score: 8.5/10
Clinical efficacy evaluation and potential mechanism prediction on Guizhi-Shaoyao-Zhimu decoction in the treatment of gouty arthritis based on meta-analysis, network pharmacology analysis, and molecular docking
Qu P et al. • Medicine (2023)
GSZD could be a satisfactory complementary and alternative therapy for treating gouty arthritis.
- GSZD could be a satisfactory complementary and alternative therapy for treating gouty arthritis.
- However, it should be verified by further studies.
- Future research on gouty arthritis could be conducted from the active components including beta-sitosterol and sitosterol, the targets including TNF-1, IL1B, and ESR1, and the signaling pathways including IL-17 and HIF-1.
Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis
Weng J et al. • Annals of medicine (2023)
The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
- The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
- NPAs identified seven hub TCM and 13 target genes associated with their actions, while bioinformatics analysis identified two DEGs between normal and CAG gastric tissues.
- Finally, molecular docking was employed to reveal the mechanism of action of the active molecules in TCM on the DEGs.
Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review
Egbuna C et al. • Current topics in medicinal chemistry (2021)
John's wort, green beans, cucumber, spinach, tea, Rosmarinus officinalis, Aloe vera, Moringa oleifera, tomatoes, potatoes, oregano, lemon balm, thyme, peppermint, Ocimum basilicum, red cabbage, pears, olive oil and walnut.
- Systematic review examining Ginkgo Biloba efficacy
- Published in Current topics in medicinal chemistry (2021)
- Further research warranted to confirm findings
Exploring the efficacy and molecular mechanism of Danhong injection comprehensively in the treatment of idiopathic pulmonary fibrosis by combining meta-analysis, network pharmacology, and molecular docking methods
Wu X et al. • Medicine (2024)
These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
- These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
- Published in Medicine (2024)
- Further research warranted to confirm findings
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus
Faysal M et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
- The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
- This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.© 2025.
A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders
Gote S et al. • Inflammopharmacology (2025)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
- The utilization of natural products holds significant promise for the prevention and treatment of neurodegenerative diseases (ND).
- The review provides evidence that natural products and their bioactive compounds could be beneficial in the treatment of neurodegenerative disorders.
- This article delineates the Keap1-Nrf2-ARE pathway's role in ND progression, shedding light on the therapeutic efficacy of natural products and their bioactive constituents that have demonstrated neuroprotective properties.© 2025.
Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review
Gonfa YH et al. • Zeitschrift fur Naturforschung. C, Journal of biosciences (2025)
The primary focus of this systematic review is to analyze the current state of the literature regarding treating liver ailments using extracts from medicinal plants, examining their phytochemical composition, and addressing associated safety considerations.© 2024 Walter de Gruyter GmbH, Berlin/Boston.
- The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity.
- Many studies, encompassing in vitro, in vivo, preclinical, and clinical investigations, have demonstrated that the extracts of medicinal plants mitigate chemical-induced liver damage using animal models.
- However, intensive research efforts regarding the safety, regulatory standard, and quality control issues for using medicinal plants as hepatoprotective agents remain the strong task of scholars.
Molecular mechanisms and therapeutic perspectives of luteolin on diabetes and its complications
Liang Q et al. • European journal of pharmacology (2025)
Luteolin may act as a pleiotropic molecule targeting multiple signaling cascades to exert antidiabetic bioactivity.
- Luteolin may act as a pleiotropic molecule targeting multiple signaling cascades to exert antidiabetic bioactivity.
- Published in European journal of pharmacology (2025)
- Further research warranted to confirm findings
NRF2 Pathway Activation as a Molecular Toxicology Mechanism in Oxidative Stress and Lipid Metabolic Disorders
Arif Asghar M et al. • Journal of biochemical and molecular toxicology (2025)
Both natural and synthetic NRF2 activators mitigate toxic lipid accumulation and oxidative injury, supporting NRF2 modulation as a promising strategy for preventing and treating lipid metabolic disorders such as NAFLD, atherosclerosis, and metabolic syndrome.© 2025 Wiley Periodicals LLC.
- Clinical meta-analysis demonstrated that NRF2 activators reduced toxic lipid parameters, including triglycerides (↓ 21.81%), LDL (↓ 18.36%), and total cholesterol (↓ 14.15%).
- Network pharmacology identified 985 overlapping genes linking NRF2 activation to oxidative stress, lipid peroxidation, and fatty acid metabolism.
- Sixteen natural and synthetic NRF2 activators were highlighted, with molecular docking showing strong KEAP1 binding by quercetin (-9.2 kcal/mol) and luteolin (-9.2 kcal/mol), consistent with disruption of KEAP1-NRF2 interactions and detoxification pathway activation.
Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug
Shao G et al. • Journal of ethnopharmacology (2024)
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- However, clinical data describing the mode of action of the naturally active compounds of POL are still lacking.
- In addition, pharmacokinetic data for POL compounds, such as changes in drug dose and absorption rates, cannot be extrapolated from animal models and need to be measured in patients in clinical trials.
Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
Nikiema WA et al. • Molecules (Basel, Switzerland) (2024)
The outcomes of this overview are to provoke structural action optimization, to orient research on particular natural chemicals for managing inflammatory, infectious diseases and cancers, or to boost vaccine immunogenicity.
- These discussed compounds exert their effects through various mechanisms, targeting the modulation of MAPKs, PI3K-Akt, and NF-kB.
- These mechanisms can support the traditional use of medicinal plants to treat immune-related diseases.
- The outcomes of this overview are to provoke structural action optimization, to orient research on particular natural chemicals for managing inflammatory, infectious diseases and cancers, or to boost vaccine immunogenicity.
Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction
O'Byrne L et al. • The Cochrane database of systematic reviews (2022)
There is very limited evidence available on the efficacy and harms of treatments for persistent olfactory dysfunction following COVID-19 infection.
- There is very limited evidence available on the efficacy and harms of treatments for persistent olfactory dysfunction following COVID-19 infection.
- However, we have identified a number of ongoing trials in this area.
- As this is a living systematic review we will update the data regularly, as new results become available.
Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review
Bischoff S et al. • Current allergy and asthma reports (2024)
Treatments such as PRP and calcium chelators demonstrated significant improvements on OFS, whereas olfactory training and corticosteroids did not show notable efficacy for COVID-19 associated olfactory dysfunction.
- Systematic review examining Luteolin efficacy
- Published in Current allergy and asthma reports (2024)
- Further research warranted to confirm findings
The favorable impacts of cardamom on related complications of diabetes: A comprehensive literature systematic review
Nasimi Doost Azgomi R et al. • Diabetes & metabolic syndrome (2024)
According to most studies, cardamom supplementation enhanced antioxidant enzyme production and activity in diabetes mellitus and decreased oxidative stress and inflammatory factors.
- According to most studies, cardamom supplementation enhanced antioxidant enzyme production and activity in diabetes mellitus and decreased oxidative stress and inflammatory factors.
- Despite this, the exact mechanism of the disease needs to be identified through more clinical trials.
- Further research warranted to confirm findings
Effects of luteolin on sepsis: A comprehensive systematic review
Vajdi M et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
Most studies revealed luteolin's positive benefits on sepsis through several pathways.
- Most studies revealed luteolin's positive benefits on sepsis through several pathways.
- Luteolin showed the capacity to reduce inflammation and oxidative stress, control immunological response, and prevent organ damage (in vivo studies) during sepsis.
- Large-scale in vivo experiments are necessary to elucidate its potential impacts on sepsis.
Effect of any form of steroids in comparison with that of other medications on the duration of olfactory dysfunction in patients with COVID-19: A systematic review of randomized trials and quasi-experimental studies
Winn PZ et al. • PloS one (2023)
Corticosteroid treatment is effective in reducing the duration of COVID-19-related smell loss and olfactory training, the basic, essential and effective intervention, should be used as a combination therapy.
- Treatment with oral corticosteroid plus olfactory training significantly improved Threshold, Discrimination and Identification (TDI) scores compared with olfactory training alone.
- Corticosteroid treatment is effective in reducing the duration of COVID-19-related smell loss and olfactory training, the basic, essential and effective intervention, should be used as a combination therapy.
- Further research warranted to confirm findings
Meta-analysis Flavonoids from traditional Chinese herbs for diabetes in rats: a network Meta-analysi
Wu Y et al. • Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan (2022)
The results of the Meta-analysis showed that naringenin, kaempferol, puerarin, baicalein, and luteolin all have clear hypoglycemic effects in rat diabetes models, highlighting their therapeutic potential for preventing and treating diabetes mellitus in clinical practice.
- The standardized mean differences (95% confidence intervals) were -4.92 (-6.67, -3.17) fornaringenin, -12 (-18.74, -5.27) for kaempferol, -2.52 (-3.77, -1.26) for puerarin, -3.04 (-5.75, -0.34) for baicalein, and -1.94 (-2.95, -0.92) for luteolin.
- The network Meta-analysis showed no statistically significant differences between the effect sizes of the flavonoids.
- The results of the Meta-analysis showed that naringenin, kaempferol, puerarin, baicalein, and luteolin all have clear hypoglycemic effects in rat diabetes models, highlighting their therapeutic potential for preventing and treating diabetes mellitus in clinical practice.
The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review
Cao Y et al. • Pharmacological research (2021)
Published by Elsevier Ltd.
- So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
- It is believed that more breakthrough studies are needed.
- Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.Copyright © 2021.
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature
Gorenshtein A et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
This systematic-review examined the effects of Luteolin.
- Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability.
- Furthermore, both rehabilitation strategies and PEA-LUT administration have been associated with improvements in symptoms of brain fog.
- Future studies should explore combinations of interventions and include longer follow-up periods to assess the long-term effects of these treatments.© 2024.
Interventions for Improving Long COVID-19 Symptomatology: A Systematic Review
Veronese N et al. • Viruses (2022)
Our systematic review found only two intervention studies focused on patients affected by long COVID-19.
- Our systematic review found only two intervention studies focused on patients affected by long COVID-19.
- More intervention studies are needed to investigate potentially positive interventions for long COVID-19 symptoms.
- Further research warranted to confirm findings