Luteolin
Luteolin
A potent anti-inflammatory flavonoid found in celery and peppers that supports brain health, reduces inflammation, and may help with allergies and mast cell disorders.
Luteolin is a flavonoid found in celery, peppers, parsley, and chamomile. It's one of the most potent natural anti-inflammatory compounds, particularly notable for its ability to cross the blood-brain barrier and reduce neuroinflammation. It inhibits mast cell activation, making it useful for allergies and histamine-related conditions. Research also suggests neuroprotective effects and potential benefits for autism spectrum disorders.
Mechanisms of Action
Anti-Inflammatory
Potent inhibitor of inflammatory pathways
Mast Cell Stabilization
Prevents histamine release
Neuroprotection
Crosses BBB to protect brain cells
Recommended Dose
100-400mg daily
Loading: Not established
Optimal Timing
- With meals
- Can divide into 2-3 doses
Take with food
Best Form
Luteolin extract or Luteolin-quercetin complex
Alternatives: Luteolin with palmitoylethanolamide (PEA), Chamomile extract (contains luteolin)
Pure luteolin has limited bioavailability. Lipid-based or complexed forms may absorb better.
Duration
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Better absorbed with fat. Often combined with quercetin or rutin for enhanced effects.
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Reduced Inflammation
Lower inflammatory markers systemically
Allergy Relief
Reduced allergic symptoms and histamine reactions
Brain Health
Neuroprotective and cognitive support
May help reduce symptoms; start low
Natural antihistamine properties
Who Should NOT Take This
- Known allergy or hypersensitivity to Luteolin or related compounds
Drug Interactions
May inhibit CYP3A4 enzyme
Possible Side Effects
Tip: Take with food
Warnings
- Limited human clinical trials
- May affect drug metabolism (CYP3A4)
- Bioavailability is variable
Top studies from 40+ peer-reviewed papers
Gonfa YH et al. • Zeitschrift fur Naturforschung. C, Journal of biosciences (2025)
“The primary focus of this systematic review is to analyze the current state of the literature regarding treating liver ailments using extracts from medicinal plants, examining their phytochemical composition, and addressing associated safety considerations.© 2024 Walter de Gruyter GmbH, Berlin/Boston.”
Key Findings:
- The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity.
- Many studies, encompassing in vitro, in vivo, preclinical, and clinical investigations, have demonstrated that the extracts of medicinal plants mitigate chemical-induced liver damage using animal models.
- However, intensive research efforts regarding the safety, regulatory standard, and quality control issues for using medicinal plants as hepatoprotective agents remain the strong task of scholars.
Gorenshtein A et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
“This systematic-review examined the effects of Luteolin.”
Key Findings:
- Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability.
- Furthermore, both rehabilitation strategies and PEA-LUT administration have been associated with improvements in symptoms of brain fog.
- Future studies should explore combinations of interventions and include longer follow-up periods to assess the long-term effects of these treatments.© 2024.
Wu X et al. • Medicine (2024)
“These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.”
Key Findings:
- These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
- Published in Medicine (2024)
- Further research warranted to confirm findings
Weng J et al. • Annals of medicine (2023)
“The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.”
Key Findings:
- The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
- NPAs identified seven hub TCM and 13 target genes associated with their actions, while bioinformatics analysis identified two DEGs between normal and CAG gastric tissues.
- Finally, molecular docking was employed to reveal the mechanism of action of the active molecules in TCM on the DEGs.
- These findings not only reveal the mechanisms of action of the active components of the TCMs, but also provide support for the development of new drugs, ultimately blocking the progression from chronic gastritis to gastric cancer.
Qu P et al. • Medicine (2023)
“GSZD could be a satisfactory complementary and alternative therapy for treating gouty arthritis.”
Key Findings:
- GSZD could be a satisfactory complementary and alternative therapy for treating gouty arthritis.
- However, it should be verified by further studies.
- Future research on gouty arthritis could be conducted from the active components including beta-sitosterol and sitosterol, the targets including TNF-1, IL1B, and ESR1, and the signaling pathways including IL-17 and HIF-1.
Study Type Distribution
Goals This Supplement Supports
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This information is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before starting any supplement.