Fisetin Research
47 peer-reviewed studies · Evidence score: 8/10
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus
Faysal M et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
- The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
- This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.© 2025.
The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases
Lu Y et al. • Advanced biology (2025)
Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.© 2025 Wiley‐VCH GmbH.
- Furthermore, SIRT6 promotes autophagy, slowing cellular senescence via the modulation of various signaling pathways, including AMPK, IGF-Akt-mTOR, H133Y, IL-1β, and mitochondrial autophagy-related proteins.
- Finally, SIRT6 regulates multiple signaling pathways, such asNF-κB, FOXO, and AMPK, to counteract the aging process.
- Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.© 2025 Wiley‐VCH GmbH.
The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review
Cao Y et al. • Pharmacological research (2021)
Published by Elsevier Ltd.
- So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
- It is believed that more breakthrough studies are needed.
- Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.Copyright © 2021.
Role of Fisetin in the Mammalian Reproductive System
Chen Y, Huang X, Zhao Z, Wang R, Liu R, Chen J, Li L, Hu M, Wei H, Zhang S. • Veterinary sciences (2026)
By consolidating current knowledge, this review aims to provide a foundation for future research and the development of natural interventions for reproductive health.
- This review provides a narrative overview of the regulatory and protective effects of Fisetin on both female and male reproductive systems, with a focus on gonadal function, the reproductive microenvironment, and endocrine regulation.
- Key molecular mechanisms, such as antioxidant, anti-inflammatory, and metabolic pathways, are discussed.
- Additionally, challenges related to low bioavailability and the translational potential in both clinical and agricultural settings are considered.
Beneficial Effects of Fisetin, a Senotherapeutic Compound, in Women's Reproductive Health and Diseases: Evidence from In Vitro to Clinical Studies
El Sayed S et al. • Nutrients (2026)
This review summarizes current experimental and clinical evidence, identifies critical gaps in mechanistic understanding, and discusses future directions for advancing fisetin as a promising non-hormonal therapeutic option in reproductive health and diseases.
- Mechanistically, fisetin regulates several pathophysiological processes, including ovarian aging, fibrosis, angiogenesis, and hormonal regulation, suggesting its potential relevance to female reproductive health and disease.
- Indeed, emerging evidence indicates that fisetin may support ovarian function and hormonal balance, modulate fibrosis and metabolism in benign gynecologic conditions, and suppress cell growth in gynecologic cancers.
- Early-phase clinical studies in non-gynecologic conditions suggest an acceptable safety profile, although evidence in reproductive health remains absent.
Exploring the Senotherapeutic Potential of Polyphenols in Aging and Disease: A Literature Review
Braučič Mitrovic L et al. • International journal of molecular sciences (2026)
It also provides a brief overview of the molecular mechanisms of senescence and attempts to identify potential drivers and barriers for the clinical translation of those nutrients.
- In recent years, cellular senescence, characterized by cell cycle arrest and development of a senescence-associated secretory phenotype (SASP), has emerged as a key mechanism of aging and ARDs and has been increasingly explored as a promising therapeutic target.
- Among dietary bioactive ingredients, fisetin and quercetin have gained attention because of their potential to act as senolytics and senomorphics.
- It also provides a brief overview of the molecular mechanisms of senescence and attempts to identify potential drivers and barriers for the clinical translation of those nutrients.
Supplement and nutraceutical therapy in traumatic brain injury
Lucke-Wold B et al. • Nutritional neuroscience (2025)
Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
- Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
- Published in Nutritional neuroscience (2025)
- Further research warranted to confirm findings
Polyphenols in the Prevention and Treatment of Colorectal Cancer: A Systematic Review of Clinical Evidence
López-Gómez L et al. • Nutrients (2024)
In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.
- Curcumin demonstrated promise in various trials, mainly decreasing inflammatory cytokines, though results varied, and it did not lower intestinal adenomas or improve outcomes after chemotherapy.
- Neither epigallocatechin gallate nor artepillin C reduced the incidence of adenomas.
- Finally, fisetin seemed to improve the inflammatory status of patients under chemotherapy (5-fluorouracil).
Nanocarriers for natural polyphenol senotherapeutics
Joma N et al. • Aging cell (2024)
Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
- Addressing challenges linked to nanocarriers, we present examples of senotherapeutic delivery to various cell types, both with and without nanocarriers.
- Finally, continued research and development of senolytic agents and nanocarriers are encouraged to reduce the undesirable effects of senescence on different cell types and organs.
- This review underscores the need for establishing reliable sets of senescence biomarkers that could assist in evaluating the effectiveness of current and future senotherapeutic candidates and nanocarriers.© 2024 The Authors.
Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review
Wendlocha D et al. • Nutrients (2023)
In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.
- The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer.
- A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated.
- This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer.
Natural Phytochemicals as SIRT Activators-Focus on Potential Biochemical Mechanisms
Wiciński M et al. • Nutrients (2023)
This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
- Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes.
- Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways.
- Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction.
Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review
Szymczak J et al. • International journal of molecular sciences (2023)
An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin's therapeutic potential to treat a particular disease.
- Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer's disease and cancer.
- Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully.
- Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy.
Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
Crocetto F et al. • Nutrients (2021)
In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.
- Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies.
- In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer.
- Further research warranted to confirm findings
Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
Kubina R et al. • Nutrients (2021)
Moreover, an attempt was made to collect the majority of substantive studies on bioactive potential of the selected flavonols, especially with regard to modulation of a range of signal transduction pathways that participate in cancer development.
- Special attention was paid to selected flavonols: fisetin, kaempferol, and quercetin in preclinical and in vitro studies.
- Study results prove antiproliferative and proapoptotic properties of flavonols with regard to head and neck cancer.
- However, few study papers evaluate specific activities during various processes associated with cancer progression.
Fisetin reduces frailty in old mice
Xu M et al. • Nature Medicine (2018)
Senolytic treatment reduced physical dysfunction in aged mice.
- Improved physical function
- Reduced frailty markers
- Cleared senescent cells
T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
Zhou S et al. • Clinical reviews in allergy & immunology (2026)
These advances underscore the potential of biomarker-guided patient stratification for future precision interventions in SLE.
- Finally, we outline therapeutic perspectives that target T-cell immunosenescence.
- These advances underscore the potential of biomarker-guided patient stratification for future precision interventions in SLE.
- Further research warranted to confirm findings
Pharmacological targeting of the senescence-associated secretory phenotype in atherosclerosis: therapeutic potential of senolytics and senomorphics
Manni E, Al-Kuraishy HM, Fawzy MN, Batiha GE. • Naunyn-Schmiedeberg's archives of pharmacology (2026)
This review offers an extensive pharmacological framework for senotherapeutics in atherosclerosis.
- Targeting SASP constitutes a rational strategy to alleviate residual inflammatory risk.
- Nonetheless, significant knowledge deficiencies persist concerning patient selection, dosing protocols, drug-drug interactions with cardiovascular treatments, and long-term safety.
- Translation necessitates stringent clinical trials in geriatric cardiovascular patients.
The Emerging Role of Senolytics as a Next-Generation Strategy Against Glioma Recurrence: A Narrative Review
Filardo A, Coscarella I, Bria J, Di Vito A, La Torre D, Chiarella E, Giovinazzo A, Procopio E, Egiziano MT, Lavano A, Della Torre A. • Cancers (2026)
We propose that the integration of senolytic adjuvants into standard clinical protocols may represent a crucial frontier for eliminating residual disease reservoirs and we also suggest the possibility of combining them with molecules with neuroprotective action to significantly improve the prognosis in GBM.
- To contrast the effects of this phenomenon, a promising therapeutic strategy has emerged, the "one-two punch," which induces initial DNA damage followed by selective elimination of senescent cells with senolytic drugs.
- In this review, we analyze in detail the efficacy of targeted synthetic agents, such as the Bcl-2 family inhibitor Navitoclax, and natural bioactive compounds such as Quercetin and Fisetin.
- The analysis focuses on the molecular mechanisms through which these agents disrupt anti-apoptotic pathways (SCAPs) and inhibit the PI3K/AKT/mTOR axis, restoring sensitivity to apoptosis.
The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial
Alipour M et al. • Nutrients (2026)
Future research employing molecular readouts is warranted to confirm the underlying pathways involved.
- Methods: Sixty sedentary men with obesity (BMI < 30 kg/m2) completed 12 weeks of thrice-weekly interval resistance training (eight exercises, 3 × 13 reps at 60% 1RM with 20% 1RM active rest), immediately followed by staged aerobic bouts (50-70% HRmax).
- Furthermore, body mass index (BMI) showed a significant inter-group difference (p = 0.021), with post hoc analysis revealing that only the TF group reached a statistically significant reduction compared to the placebo (p = 0.024; 95% CI [-3.760, -0.172]).
- The findings indicated that the TF group experienced the most substantial reductions in both asprosin (-60.71%) and MCP-1 (-46.50%) levels.
Emerging Therapeutic Potential of Fisetin for Nephrotoxicity, Kidney Injury, and Nephropathy: A Systematic Review
Mohajeri S, Jouneghani AS, Heidari-Soureshjani S, Sherwin CM, Beigi F. • Current diabetes reviews (2026)
Preclinical studies revealed that FIS demonstrates promising protective effects against kidney toxicity, renal injury, diabetes, and lupus-induced nephropathy.
- Additionally, modulation of metabolic pathways was observed, including decreased glucose and lipid profiles and improved insulin sensitivity.
- Kidney function and structural integrity were preserved with reduced levels of nephrotoxic agents.
- Conclusion Preclinical studies revealed that FIS demonstrates promising protective effects against kidney toxicity, renal injury, diabetes, and lupus-induced nephropathy.