Fisetin
Fisetin (3,3',4',7-tetrahydroxyflavone)
Flavonoid with potent senolytic properties, may clear damaged cells and support healthy aging.
Fisetin is a flavonoid found in strawberries, apples, and other plants. It's gained significant attention in longevity research as a potent senolytic — a compound that selectively eliminates senescent (damaged, 'zombie') cells that accumulate with age and contribute to aging and disease. Animal studies show remarkable effects, and human trials are underway.
Mechanisms of Action
Senolytic Activity
Selectively eliminates senescent cells
Antioxidant
Neutralizes free radicals
Anti-Inflammatory
Reduces inflammatory signaling
Recommended Dose
100-500mg (intermittent dosing for senolytic effect)
Loading: Some use 'senolytic dosing': 500-1500mg for 2 consecutive days, once monthly
Optimal Timing
- With meals containing fat
Take with food
Best Form
Fisetin capsules or powder
Alternatives: Liposomal fisetin
Bioavailability is limited. Enhanced forms may improve absorption.
Duration
Minimum: 4 weeks
Optimal: weeks
Cycling: For senolytic effect: some researchers suggest 2-3 days of high-dose (500-1500mg) monthly or quarterly. Daily low-dose use is also studied.
Note: Fat improves absorption. For senolytic purposes, intermittent high-dose protocols are sometimes used.
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Senescent Cell Clearance
Reduces burden of damaged cells
Reduced Inflammation
Lower inflammatory markers
Avoid — affects cellular processes
Consult oncologist — senolytics may have complex effects
Who Should NOT Take This
- Pregnancy (affects cell processes)
Drug Interactions
May have antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Possible Side Effects
Tip: Take with food
Warnings
- Human longevity data is limited — most evidence from animal studies
- Optimal dosing protocol not yet established
- Long-term safety in humans not fully characterized
Top studies from 40+ peer-reviewed papers
Lucke-Wold B et al. • Nutritional neuroscience (2025)
“Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.”
Key Findings:
- Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
- Published in Nutritional neuroscience (2025)
- Further research warranted to confirm findings
López-Gómez L et al. • Nutrients (2024)
“In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.”
Key Findings:
- Curcumin demonstrated promise in various trials, mainly decreasing inflammatory cytokines, though results varied, and it did not lower intestinal adenomas or improve outcomes after chemotherapy.
- Neither epigallocatechin gallate nor artepillin C reduced the incidence of adenomas.
- Finally, fisetin seemed to improve the inflammatory status of patients under chemotherapy (5-fluorouracil).
- In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.
Joma N et al. • Aging cell (2024)
“Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.”
Key Findings:
- Addressing challenges linked to nanocarriers, we present examples of senotherapeutic delivery to various cell types, both with and without nanocarriers.
- Finally, continued research and development of senolytic agents and nanocarriers are encouraged to reduce the undesirable effects of senescence on different cell types and organs.
- This review underscores the need for establishing reliable sets of senescence biomarkers that could assist in evaluating the effectiveness of current and future senotherapeutic candidates and nanocarriers.© 2024 The Authors.
- Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
Wendlocha D et al. • Nutrients (2023)
“In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.”
Key Findings:
- The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer.
- A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated.
- This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer.
- In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.
Wiciński M et al. • Nutrients (2023)
“This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.”
Key Findings:
- Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes.
- Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways.
- Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction.
- This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
Study Type Distribution
Goals This Supplement Supports
Related Goals
This information is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before starting any supplement.