Does Nutrition Intervention Prevent and Heal Pressure Injury? A Systematic Review of Randomized Controlled Trials
Yildirim D et al. • Advances in skin & wound care (2026)
Across 18 studies including 1231 participants (aged 38 to 83 y) with stage 2 to 4 PIs, nutritional interventions demonstrated positive effects on prevention and healing.
Across 18 studies including 1231 participants (aged 38 to 83 y) with stage 2 to 4 PIs, nutritional interventions demonstrated positive effects on prevention and healing.
Formulas enriched with protein, arginine, zinc, antioxidants, and other nutrients appear promising; nonetheless, further large-scale, high-quality RCTs are needed to confirm these findings.
Efficacy and mechanisms of Xiangsha Liujunzi Decoction for gastroesophageal reflux disease: A study integrating meta-analysis, network pharmacology and molecular docking
Tian M et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.
Eight RCTs (n = 646) showed that XSLJZD significantly improved clinical outcomes compared with controls, demonstrating superior overall efficacy and reduced recurrence.
XSLJZD may improve RE symptoms as an adjunctive therapy, but the evidence is low in certainty.
The proposed anti-inflammatory and apoptotic mechanisms are computationally derived.
Efficacy and safety of boron neutron capture therapy for locally recurrent head and neck cancer
Sun X et al. • Critical reviews in oncology/hematology (2026)
BNCT has shown favorable efficacy and safety in LRHNC.
The ORR was 70 % (95 % CI: 65 %-75 %; P = 0.8187) and the 2-year OS rate was 45 % (95 % CI: 39 %-50 %; P < 0.0001).
The ORR of patients with non-squamous cell carcinoma (NSCC) was higher than those with squamous cell carcinoma (SCC) (82 % vs. 72 %), while the 2-year OS rates were similar (50 % vs. 49 %).
The most frequent acute AEs included hyperamylasemia (75 %, 95 % CI: 70 %-80 %), alopecia (61 %, 95 % CI: 55 %-67 %), and submandibular gland inflammation (61 %, 95 % CI: 49 %-72 %).
Wu X et al. • Journal of gastroenterology and hepatology (2026)
The relationship between caffeine intake and IBD risk varies by region, age, caffeine source, smoking, and education level.
The meta-analysis showed no significant association between caffeine intake and IBD (RR = 0.84, 95% CI = 0.68-1.04).
In Americans, caffeine increased UC risk by 68% (RR = 1.68, 95% CI = 1.17-2.42).
Age analysis showed caffeine increased IBD risk by 4.52 times in those ≤18 (RR = 4.52, 95% CI = 1.59-12.88) but decreased risk by 7% in those >18 (RR = 0.93, 95% CI = 0.73-1.18).
Drug delivery and formulation development of hesperidin: a systematic review
Hoang TPN et al. • Expert opinion on drug delivery (2026)
Formulation advances can significantly mitigate hesperidin's biopharmaceutical liabilities, with lipid-based systems, polymeric nanoparticles, and phytosomes emerging as leading strategies.
Formulation advances can significantly mitigate hesperidin's biopharmaceutical liabilities, with lipid-based systems, polymeric nanoparticles, and phytosomes emerging as leading strategies.
Translation will benefit from stability and immunotoxicity packages, quality-by-design manufacturing, and well-designed, adequately powered clinical trials using harmonised pharmacokinetic and clinical endpoints.
Pharmacovigilance and toxicological risks associated with apitherapeutic products: a systematic overview
Rocha Filho LKA et al. • Archives of toxicology (2026)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Allergic responses were the most prevalent type of adverse event, particularly among atopic individuals.
These findings highlight the need for appropriate labeling, post-marketing surveillance, and educational campaigns to ensure the safe use of these products.
Krishnan N • Advances in experimental medicine and biology (2026)
The Author(s), under exclusive license to Springer Nature Switzerland AG.
On the other hand, neuropeptides such as neuropeptide F, allatostatin-A, corazonin, leukokinin, tachykinins, limostatins, and insulin-like growth factor (ILP6) stimulate lipolysis.
This chapter briefly discusses the current knowledge of the endocrine regulation of lipid metabolism in insects that could be utilized to reveal differences between insects and mammalian lipid metabolism which may help understand human diseases associated with dysregulation of lipid metabolism.
Mushrooms and Their Bioactive Ingredients as Natural Resources for Development of Innovative Skin Care Formulations and Products
Janardhanan KK et al. • International journal of medicinal mushrooms (2026)
This review outlines the importance of mushrooms and their bioactive ingredients for development of skin care formulations and products in the multibillion-dollar cosmetic industry.
Mushroom based cosmetic products have substantial world market especially in USA, China, UK, Korea and Japan.
Mushroom cosmetic market presents promising opportunities for expansion because of the growing demands of aging solutions.
Global demand is predicted to reach nearly 3.9 billion USD by 2032.
Application of Medicinal Mushrooms for the Treatment of Peripheral Nerve Injury: A Systematic Review
Taib NAB et al. • Medical sciences (Basel, Switzerland) (2026)
Conclusions: Despite presenting the potential use of mushrooms in managing PNIs, the existing approaches need to be subjected to clinical research to accelerate the development of future therapeutics and preventive measures for PNIs.
Results: These mushroom-derived treatments enhanced the migration of Schwann cells mainly via the FGF-2 signalling and MAPK pathway.
In vivo studies also revealed the ability of H. erinaceus, A. muscaria, and L. rhinocerotis to promote peripheral nerve repair and functional recovery, with evidence suggesting the role of neurotrophic factors, anti-apoptotic signalling, and pro-inflammatory substances.
H. erinaceus was identified as the most promising for potential clinical applications, given the stronger evidence-based data and its relatively safer components compared to A. muscuria and other mushroom species.
Aquatic collagen for tissue repair: process-structure-function design from sustainable sourcing to clinical translation
Xiong X et al. • Acta biomaterialia (2026)
Published by Elsevier Inc.
By benchmarking aquatic versus mammalian collagens and distilling design rules for printable, mineralized and antimicrobial hydrogels/bioinks, we show how waste valorization can reduce environmental burden while meeting functional demands in wound, musculoskeletal, ocular and cardiac repair.
We also identify standardization gaps-including source variability, purity/endotoxin specifications and batch analytics-and propose practical reporting checklists to improve reproducibility and regulatory readiness.
Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use
Ulpathakumbura S et al. • Ageing research reviews (2026)
All rights reserved.
Despite supporting preliminary data and patented formulations, strong scientific evidence encouraging the synergistic anti-aging potential of PQQ and NMN/NR remains limited, highlighting the need for robust studies.
Protective effects of pyrroloquinoline quinone in CNS disorders
Aboulhassane S et al. • The Journal of nutritional biochemistry (2026)
All rights reserved.
This review will address the biochemical properties, mechanism of action, and physiological roles of PQQ with a specific focus on its antioxidant and anti-inflammatory effects as well as its role in enhancing mitochondrial function.
Ellagitannins from red raspberry (Rubus idaeus L.): a comprehensive review on chemistry characteristics and beneficial effects
Tao M et al. • Food & function (2026)
It aims to provide the food science and nutrition community with an authoritative reference on ellagitannins in red raspberry and to guide their development and application as core ingredients for next-generation functional foods and nutraceuticals.
In red raspberry (Rubus idaeus L.), ellagitannins constitute the predominant class of polyphenols, accounting for 53-76% of the total polyphenolic content, and their health-promoting potential is becoming increasingly evident.
This review systematically delineates the chemical structures of ellagitannins, extraction and analytical techniques, in vivo metabolic pathways, and their multiple biological activities.
It aims to provide the food science and nutrition community with an authoritative reference on ellagitannins in red raspberry and to guide their development and application as core ingredients for next-generation functional foods and nutraceuticals.
Comprehensive characterization of Rubus idaeus L. Polysaccharides: Extraction, purification, structural diversity, biological efficacy, and structure-activity relationships
Gao S et al. • Journal of ethnopharmacology (2026)
RP is among the key bioactive constituents of Rubus idaeus L.
RP is among the key bioactive constituents of Rubus idaeus L.
This review provides a comprehensive summary of the extraction, isolation, purification, biological activities, and structure-activity relationships of RP, offering valuable reference and support for their applications in pharmaceuticals, food products, nutraceuticals, and cosmetics.