Turkey Tail Research
36 peer-reviewed studies · Evidence score: 7/10
A Scoping Review of Complementary and Alternative Medicine for Human Papillomavirus Infections and Cervical Dysplasia
Walsh CJ et al. • Journal of lower genital tract disease (2024)
The evidence for treating HPV and cervical dysplasia with CAM is of low quality because of lack of standardized, clinically relevant treatment outcomes, lack of standardization of products, and minimal reporting on adverse and long-term effects.
- Adverse events were reported in only 28/56 (50%) of included studies.
- The evidence for treating HPV and cervical dysplasia with CAM is of low quality because of lack of standardized, clinically relevant treatment outcomes, lack of standardization of products, and minimal reporting on adverse and long-term effects.
- Future large, randomized control trials are needed to further assess efficacy and safety of CAM therapies to address HPV and cervical dysplasia.
Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer
Pilkington K et al. • The Cochrane database of systematic reviews (2022)
Due to the very low certainty of evidence, we were uncertain about the effect of adjunctive Coriolus (in the form of an extract PSK) on adverse events resulting from conventional chemotherapy for colorectal cancer.
- We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
- Due to the very low certainty of evidence, we were uncertain about the effect of adjunctive Coriolus (in the form of an extract PSK) on adverse events resulting from conventional chemotherapy for colorectal cancer.
- This includes effects on withdrawal of treatment due to adverse events and on specific adverse outcomes such as neutropenia and nausea.
Fungal Polysaccharides as Modulators of Molecular Pathways in Liver Health
Szelenberger R et al. • Molecules (Basel, Switzerland) (2025)
Presented evidence indicates that fungal polysaccharides possess considerable potential as multifunctional hepatoprotective agents, highlighting the need for further mechanistic insight and clinical validation.
- Fungal polysaccharides were also shown to improve hepatic function by lowering serum biomarkers of liver injury and ameliorating histopathological damage.
- Presented evidence indicates that fungal polysaccharides possess considerable potential as multifunctional hepatoprotective agents, highlighting the need for further mechanistic insight and clinical validation.
- Further research warranted to confirm findings
Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review
Łysakowska P et al. • Molecules (Basel, Switzerland) (2023)
This review focuses on the properties of selected medicinal mushrooms and their effects on the human organism and presents current knowledge on the possibilities of their use in the production of functional foods.
- Detailed mechanisms of the effects of medicinal mushrooms on the human organism still require long-term clinical studies to confirm their nutraceutical effects, their safety of use, and their dosage.
- Medicinal mushrooms have great potential to be used in the design of innovative functional foods.
- There is a need for further research on the possibility of incorporating mushrooms into food products to assess the interactions of their bioactive substances with ingredients in the food matrix.
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
Gariboldi MB et al. • International journal of molecular sciences (2023)
We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
- In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
- In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus.
- We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy
Shahrajabian MH et al. • Current HIV research (2023)
The aim of this review article is to survey and introduce important medicinal plants and herbs that have been used for the treatment of HIV, especially the medicinal plants that are common in traditional Chinese medicine, as research to date is limited, and more evidence is required to confirm TCM,s efficacy.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
- Terpenes inhibit virus fusion, lectins and flavonoids have an inhibitory impact on viral binding, curcumin and flavonoids inhibit viral DNA integration.
- The information provided is gathered from randomized control experiments, review articles, and analytical studies and observations, which are obtained from different literature sources, such as Scopus, Google Scholar, PubMed, and Science Direct from July 2000 to August 2023.
- Further research warranted to confirm findings
Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms
Xu J et al. • Nutrients (2022)
In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.
- Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
- Additionally, few studies have reported the safety and efficacy of extracts from edible and medicinal fungi, which may limit their clinical application.
- In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.
Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties-A Review on Hong Kong's Experience
Yue GG et al. • Molecules (Basel, Switzerland) (2021)
While immune modulation platforms are being built for relevant studies, a brief account on the research targets and related procedures are given.
- Nine of them have been selected to give the results of our exploration on their biological, particularly immunomodulatory activities.
- Since Hong Kong people especially favor one medicinal mushroom, viz.
- Coriolus versicolor, a number of clinical trials using Coriolus for cancer-related studies are included in this review.
Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings
Hou YN et al. • Cancer journal (Sudbury, Mass.) (2019)
It is important to familiarize health care professionals about popular supplements, so patients can be informed to make decisions that maximize benefits and minimize risks.
- The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexose-Correlated Compound, boswellia, dandelion, green tea, and Coriolus versicolor.
- Here we discuss their safety, herb-drug interactions, and appropriate uses in the oncology setting, based on literature searches in PubMed.
- Over the past 16 years, the evidence for use of these supplements is based mostly on preclinical findings, with few well-designed studies and limited trials conducted in cancer patients.
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies
Narayanan S et al. • Current oncology reports (2023)
More trials are needed to explore mushroom use during and after cancer treatment.
- Systematic review examining Cordyceps efficacy
- Published in Current oncology reports (2023)
- Further research warranted to confirm findings
Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials
Wong JH et al. • Applied microbiology and biotechnology (2020)
Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
- This article reviews mushrooms with anti-breast cancer activity.
- Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
- Further research warranted to confirm findings
Immunostimulatory and anticancer effect of Reishi and Coriol extracts at the level of clinical studies and their implementation in practice
Neuwirthová J et al. • Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2020)
Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
- Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
- Moreover, they have prolonged their disease-free interval and overall survival.
- They are well tolerated even in advanced cancer diseases and could be safely used continuously for long periods of time.
Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China
Dou H et al. • Progress in molecular biology and translational science (2019)
All rights reserved.
- The polysaccharide content in PSP is ~60% and the peptide content in PSP is ~10-30%.
- In recent years, immunotherapy has been widely used in cancer treatment.
- However, to use PSP as an immunotherapeutic at world stage, further chemical, biochemical and pharmacological studies of PSP are needed.© 2019 Elsevier Inc.
Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants
Wong JH et al. • Current medicinal chemistry (2018)
These compounds have the potential of development into anticancer drugs.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
- The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants.
- The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus.
- The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia.
Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China
Chang Y et al. • Discovery medicine (2017)
However, the complicated chemical and multiple pharmacological properties of PSP need to be investigated further.
- Its immunomodulatory and anti-tumor molecular mechanisms are also summarized.
- The clinical studies support PSP being a potential immunotherapeutic.
- However, the complicated chemical and multiple pharmacological properties of PSP need to be investigated further.
Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review
Fritz H et al. • Integrative cancer therapies (2015)
PSK may improve immune function, reduce tumor-associated symptoms, and extend survival in lung cancer patients.
- PSK may improve immune function, reduce tumor-associated symptoms, and extend survival in lung cancer patients.
- Larger, more rigorous randomized controlled trials for PSK in lung cancer patients are warranted.
- Further research warranted to confirm findings
[Immunomodulatory and antitumor properties of polysaccharide peptide (PSP)]
Piotrowski J et al. • Postepy higieny i medycyny doswiadczalnej (Online) (2015)
Because of its unique properties and safety, PSP may become a widely used therapeutic agent in the near future.
- Its anti-tumor effects seemed to be mediated through immunomodulatory regulation.
- PSP stimulates cells of the immune system, induces synthesis of cytokines such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α), eicosanoids including prostaglandin E2 (PGE2), histamine, reactive oxygen species and nitrogen mediators.
- There is a growing interest in understanding the mechanisms of PSP action.
PSK immunotherapy for gastric cancer
Oba K et al. • Cancer Immunology, Immunotherapy (2007)
PSK significantly improved survival in gastric cancer patients.
- Improved survival rates
- Enhanced immune parameters
- Well-tolerated as adjunct therapy
Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis
Eliza WL et al. • Recent patents on inflammation & allergy drug discovery (2012)
This meta-analysis has provided strong evidence that Yun Zhi would have survival benefit in cancer patients, particularly in carcinoma of breast, gastric and colorectal.
- Of patient randomized to Yun Zhi, there was a 9% absolute reduction in 5-year mortality, resulting in one additional patient alive for every 11 patients treated.
- This meta-analysis has provided strong evidence that Yun Zhi would have survival benefit in cancer patients, particularly in carcinoma of breast, gastric and colorectal.
- Nevertheless, the findings highlight the need for further evidence from prospective studies of outcome to guide future potential modifications of treatment regimes.
Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators
Spelman K et al. • Alternative medicine review : a journal of clinical therapeutic (2006)
The in vitro and in vivo research demonstrates that the reviewed botanical medicines modulate the secretion of multiple cytokines.
- The in vitro and in vivo research demonstrates that the reviewed botanical medicines modulate the secretion of multiple cytokines.
- The reported therapeutic success of these plants by traditional cultures and modern clinicians may be partially due to their effects on cytokines.
- Phytotherapy offers a potential therapeutic modality for the treatment of many differing conditions involving cytokines.