Skullcap Research
37 peer-reviewed studies · Evidence score: 5.5/10
Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review
Weiner JD et al. • Lupus science & medicine (2025)
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
- We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
- This article may serve as a reference to help clinicians counsel patients with autoimmune skin diseases on the risks associated with use of specific herbal supplements.
- Further research warranted to confirm findings
Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis
Xiong X et al. • Pharmacological research (2020)
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- Besides, no severe adverse effects was identified by CHM.
- CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.Copyright © 2020 The Author(s).
- Published by Elsevier Ltd..
Baicalin and baicalein against myocardial ischemia-reperfusion injury: A review of the current documents
Nasiri R et al. • Tissue & cell (2025)
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- Research in both animal and cell models suggests that these flavonoids, especially baicalin, can restore cardiac health following MIRI, improving cardiac performance, and reducing cardiac damage.
- These findings underscore the potential of baicalin and baicalein as therapeutic options for MIRI.
- However, further research and clinical trials are necessary to elucidate their mechanisms fully and to develop baicalin into a viable treatment.Copyright © 2025 Elsevier Ltd.
Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases
Chmiel M et al. • International journal of molecular sciences (2023)
In this review, we summarized the latest reports on one of the most important aglycones with respect to the pharmacological activity and high content in Baikal skullcap, which is 5,6,7-trihydroxyflavone (baicalein).
- It has been documented that the extract of Baikal skullcap (Scutellaria baicalensis) has hepatoprotective, calming, antiallergic, and anti-inflammatory properties.
- Flavonoid compounds found in the extract, including baicalein, have strong antiradical activity, which improves overall health and increases feelings of well-being.
- Plant-derived bioactive compounds with antioxidant activity have for a long time been used as an alternative source of medicines to treat oxidative stress-related diseases.
Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation
Patel S et al. • Current psychiatry reports (2024)
Evaluating benefit versus risk ratios and reviewing drug-drug interactions is essential to promote transplant candidacy and mitigate the possibility of native or graft liver dysfunction.
- Systematic review examining Skullcap efficacy
- Published in Current psychiatry reports (2024)
- Further research warranted to confirm findings
Wogonin, as a potent anticancer compound: From chemistry to cellular interactions
Tuli HS et al. • Experimental biology and medicine (Maywood, N.J.) (2023)
This review will encourage researchers to generalize the merits of wogonin to be used as potential compound for cancer treatment.
- This review focuses on a complete overview of published reports that suggest chemopreventive action of wogonin and the mechanistic insights behind these neoplastic activities.
- It also emphasizes the synergistic improvements made by wogonin in chemoprevention.
- The factual data in this mini-review stimulate additional research on chemistry and toxicological profile of wogonin to confirm its safety issues.
Wogonin and its analogs for the prevention and treatment of cancer: A systematic review
Banik K et al. • Phytotherapy research : PTR (2022)
These studies propound the use of WOG as a potential anticancer candidate; however, further high-quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.© 2022 John Wiley & Sons Ltd.
- WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity.
- Nevertheless, human trials are warranted to validate these findings.
- Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug.
Japanese herbal medicine-induced pneumonitis: A review of 73 patients
Enomoto Y Md et al. • Respiratory investigation (2017)
Clinicians should be cautious regarding JHM-induced pneumonitis, particularly when using drugs/ingredients known to cause this complication, and during the early treatment period.
- Among the various JHMs reported, sho-saiko-to was the most frequently used drug (26%), followed by sairei-to (16%), seishin-renshi-in (8%), and bofu-tsusyo-san (8%).
- Sixty-five patients (89%) developed pneumonitis within 3 months of beginning JHM treatment.
- Twenty-six patients (36%) recovered from the pneumonitis after simply discontinuing the causative JHM.
GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence
Savage K et al. • Phytotherapy research : PTR (2018)
Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.Copyright © 2017 John Wiley & Sons, Ltd.
- An open-ended search to 5 July 2017 was conducted using MEDLINE (PubMed), Scopus, and Cochrane library online databases and performed in a stepped format from preclinical to clinical investigations.
- Eligible studies must have had (a) in vitro evidence of GABA-modulating activity, (b) animal studies using anxiety models to test an anxiolytic effect, and (c) human clinical trials.
- Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm.
Timing for cranioplasty to improve neurological outcome: A systematic review
De Cola MC et al. • Brain and behavior (2018)
It is believed that cranioplasty performed from 3 to 6 months after DC may significantly improve both motor and cognitive recovery.
- It is believed that cranioplasty performed from 3 to 6 months after DC may significantly improve both motor and cognitive recovery.
- Published in Brain and behavior (2018)
- Further research warranted to confirm findings
Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways
Huynh DL et al. • Chinese journal of natural medicines (2017)
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- We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment.
- Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.Copyright © 2017 China Pharmaceutical University.
- Published by Elsevier B.V.
[Analysis of Medication Laws for Chinese Medicine Treating Hypertension Patients with Yin Defi- ciency Yang Hyperactivity Syndrome Based on Literatures]
Ma N et al. • Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (2016)
Medication laws of CM treatment in hypertension patientswith yin deficiency yang hyperactivity syndrome obtained by analysis of complex networks reflected thetherapeutics of nourishing yin to suppress yang, which could further provide reference for clinical studies.
- Medication laws of CM treatment in hypertension patientswith yin deficiency yang hyperactivity syndrome obtained by analysis of complex networks reflected thetherapeutics of nourishing yin to suppress yang, which could further provide reference for clinical studies.
- Published in Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (2016)
- Further research warranted to confirm findings
Flavocoxid, a nutraceutical approach to blunt inflammatory conditions
Bitto A et al. • Mediators of inflammation (2014)
Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.
- Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro.
- Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models.
- Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen.
[Morphology and phenomenology of crossbow injuries with a review of the literature]
Kernbach-Wighton G et al. • Archiv fur Kriminologie (2014)
Morphology of the wounds, ballistic features and technical characteristics are discussed and the available literature is reviewed.
- Case no. 1 is characterised by repeated assaults resulting in severe injuries to the legs of the victim.
- The lesions showed characteristic patterns due to the arrow-heads with four cross-shaped blades.
- Case no. 2 represented a suicide with the crossbow arrow entering the upper mouth region at close range, penetrating the base of the skull, the pons and the inter-hemispheric space, with the tip of the arrow being lodged in the skullcap.
Review article: herbal and dietary supplement hepatotoxicity
Bunchorntavakul C et al. • Alimentary pharmacology & therapeutics (2013)
A number of herbal medicinal products are associated with a spectrum of hepatotoxicity events.
- A number of herbal medicinal products are associated with a spectrum of hepatotoxicity events.
- Advances in the understanding of the pathogenesis and the risks involved are needed to improve herbal medicine safety.
- Further research warranted to confirm findings
Ligand- and protein-based modeling studies of the inhibitors of human cytochrome P450 2D6 and a virtual screening for potential inhibitors from the Chinese herbal medicine, Scutellaria baicalensis (Huangqin,Baikal Skullcap)
Mo SL et al. • Combinatorial chemistry & high throughput screening (2012)
Our study has provided insights into the molecular mechanisms of interaction of synthetic and herbal compounds with human CYP2D6 and further benchmarking studies are needed to validate our modeling and virtual screening results.
- Apparent changes in the binding modes of the inhibitors have been observed with Phe120Ile, Glu216Asp, Asp301Glu mutations in CYP2D6.
- Finally, we screened for potential binders/inhibitors from the Chinese herbal medicine Scutellaria baicalensis (Huangqin, Baikal Skullcap) using the established pharmacophore model for CYP2D6 inhibitors and molecular docking approach.
- Overall, 18 out of 40 compounds from S. baicalensis were mapped to the pharmacophore model of CYP2D6 inhibitors and most herbal compounds from S. baicalensis could be docked into the active site of CYP2D6.
Herbs in epilepsy: evidence for efficacy, toxicity, and interactions
Pearl PL et al. • Seminars in pediatric neurology (2011)
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- Herb-drug interactions also occur at the level of the P450 hepatic enzyme system of drug catabolism and the P-glycoprotein transport system regulating the entry of exogenous compounds into the vasculature or blood-brain barrier.
- Thus, significant pharmacokinetic interactions may occur, in addition to pharmacodynamic interactions and proconvulsant effects of alternative medications themselves.
- All rights reserved.
Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian
Weeks BS • Medical science monitor : international medical journal of experimental and clinical research (2009)
While questions remain in the literature regarding the medicinal value of these supplements in treating mood and anxiety disorders, based on cellular and animal studies as well as human clinical trials the literature supports a role for these preparations as useful alternatives in the management of the stress and anxiety of everyday life.
- Further, extracts of Magnolia and Phellondendron bark are mild sedatives.
- Supplements such as gamma-aminobutyric acid (GABA), theanine, tryptophan and 5-hydroxytryptophan (5-HTP) are reported to promote relaxation.
- In general, these supplements appear to act as GABA receptor agonists or to boost GABA levels, although Kava inhibits both norephinephrine uptake and sodium and potassium channels and 5-HTP may act through elevation of serotonin.
Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature
Linnebur SA et al. • Pharmacotherapy (2010)
Patients seeking dietary supplements for osteoarthritis may want to avoid glucosaminechondroitin products such as Move Free Advanced that also contain Chinese skullcap.
- Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 6 for both patients) between the patients' development of hepatotoxicity and the Move Free Advanced supplement.
- Based on a review of the literature, the herbal extract Chinese skullcap is the most likely cause of the hepatotoxicity.
- To our knowledge, these two cases are the first to be published regarding possible hepatotoxicity associated with Move Free Advanced.
Targeting angiogenesis with integrative cancer therapies
Yance DR Jr et al. • Integrative cancer therapies (2006)
Although controlled trials might be preferred, smaller studies with appropriate end points and surrogate markers for antiangiogenic response could help prioritize agents for the larger resource-intensive phase 3 trials.
- In this role, they act as biological response modifiers and adaptogens, potentially enhancing the efficacy of the so-called conventional therapies.
- Their effectiveness may be increased when multiple agents are used in optimal combinations.
- New designs for trials to demonstrate activity in human subjects are required.