Quercetin Research
48 peer-reviewed studies · Evidence score: 8/10
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Liang H et al. • Renal failure (2025)
Through rigorous experimental validation, our study demonstrates AS's significant clinical efficacy in managing DN.
- Meanwhile, when the treatment duration exceeds 12 weeks, AS demonstrated a significant reduction in fasting blood glucose levels, indicating a time-dependent effect.
- Through rigorous experimental validation, our study demonstrates AS's significant clinical efficacy in managing DN.
- Specifically, AS has been shown to enhance renal function, ameliorate renal fibrosis, and positively influence iron metabolism.
Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer
Okselni T et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Furthermore, quercetin significantly inhibited tyrosinase activity (Z-score, 1.95), resulting in a significantly reduced melanin content (Z-score, 2.56).
- A significant reduction in DNA damage (Z-score, 3.27), melanoma cell viability (Z-score, 2.97), and tumor formation was also observed to ensure the promising activity of quercetin for skin issues.
- This review highlights quercetin's potential as a multifaceted agent in skin care and treatment.© 2024.
Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis
Zhou P et al. • PloS one (2024)
The rankings of safety and efficacy of the 12 antioxidants vary.
- The rankings of safety and efficacy of the 12 antioxidants vary.
- Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
- More high-quality studies are still needed to verify our findings.
Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis
Wu D et al. • Frontiers in immunology (2025)
This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
- This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
- Curcumin and salidroside can improve the course of COPD by regulating blood pressure, inflammation, and the coagulation pathway, supporting the hypothesis of "polyphenol targeting of metabolic-inflammatory networks".
- However, the possible negative effects of anthocyanins warn against ingredient heterogeneity.
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials
Long Z et al. • Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
- Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
- However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
- Further research warranted to confirm findings
Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis
Weng J et al. • Annals of medicine (2023)
The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
- The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.
- NPAs identified seven hub TCM and 13 target genes associated with their actions, while bioinformatics analysis identified two DEGs between normal and CAG gastric tissues.
- Finally, molecular docking was employed to reveal the mechanism of action of the active molecules in TCM on the DEGs.
Micronutrient Supplementation to Reduce Cardiovascular Risk
An P et al. • Journal of the American College of Cardiology (2022)
Supplementation of some but not all micronutrients may benefit cardiometabolic health.
- Specifically, n-3 fatty acid supplementation decreased CVD mortality (relative risk [RR]: 0.93; 95% CI: 0.88-0.97), myocardial infarction (RR: 0.85; 95% CI: 0.78-0.92), and coronary heart disease events (RR: 0.86; 95% CI: 0.80-0.93).
- Folic acid supplementation decreased stroke risk (RR: 0.84; 95% CI: 0.72-0.97), and coenzyme Q10 supplementation decreased all-cause mortality events (RR: 0.68; 95% CI: 0.49-0.94).
- Supplementation of some but not all micronutrients may benefit cardiometabolic health.
Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review
Egbuna C et al. • Current topics in medicinal chemistry (2021)
John's wort, green beans, cucumber, spinach, tea, Rosmarinus officinalis, Aloe vera, Moringa oleifera, tomatoes, potatoes, oregano, lemon balm, thyme, peppermint, Ocimum basilicum, red cabbage, pears, olive oil and walnut.
- Systematic review examining Ginkgo Biloba efficacy
- Published in Current topics in medicinal chemistry (2021)
- Further research warranted to confirm findings
Substance basis and pharmacological mechanism of heat-clearing herbs in the treatment of ischaemic encephalopathy: a systematic review and network pharmacology
Zhao A et al. • Annals of medicine (2024)
Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
- Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
- It can be seen that the components of heat-clearing Chinese medicines can exert cerebroprotective effects through multiple pathways, which provides us with a reference for further development and study of heat-clearing Chinese medicines in the treatment of ischemic cerebrovascular diseases.
- Further research warranted to confirm findings
Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies
Liu L et al. • Food chemistry (2025)
All rights reserved.
- This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans.Copyright © 2025 The Authors.
- Published by Elsevier Ltd..
- All rights reserved.
Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis
Huang H et al. • Nutrition reviews (2020)
Quercetin intake resulted in significantly decreased BP in humans.
- Pooled results showed that quercetin significantly lowered both systolic BP (WMD, -3.09 mmHg; 95%CI, -4.59 to -1.59; P = 0.0001) and diastolic BP (WMD, -2.86 mmHg; 95%CI, -5.09 to -0.63; P = 0.01).
- Quercetin intake resulted in significantly decreased BP in humans.
- Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design.
Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis
Wu X et al. • Inflammopharmacology (2025)
Herein, our study highlights the potential of quercetin in the treatment of PF and the available mechanisms.
- Herein, our study highlights the potential of quercetin in the treatment of PF and the available mechanisms.
- Published in Inflammopharmacology (2025)
- Further research warranted to confirm findings
Molecular mechanisms and therapeutic potential of quercetin in ovarian functions
Zhang X et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)
This review underscores the potential of quercetin as a promising therapeutic agent for managing ovarian-related reproductive disorders.
- This review underscores the potential of quercetin as a promising therapeutic agent for managing ovarian-related reproductive disorders.
- Given its diverse biological activities, quercetin may offer significant clinical benefits in female reproductive medicine.
- Nonetheless, further investigations are warranted to determine its long-term efficacy, optimal dosing strategies, and specific molecular targets across various ovarian pathologies.
Quercetin and inflammatory markers: A meta-analysis
Mohammadi-Sartang M et al. • Pharmacological Research (2017)
Quercetin significantly reduced CRP levels, especially at higher doses.
- Reduced C-reactive protein
- Anti-inflammatory effects confirmed
- Effects dose-dependent
Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug
Shao G et al. • Journal of ethnopharmacology (2024)
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- However, clinical data describing the mode of action of the naturally active compounds of POL are still lacking.
- In addition, pharmacokinetic data for POL compounds, such as changes in drug dose and absorption rates, cannot be extrapolated from animal models and need to be measured in patients in clinical trials.
A Systematic Review of the Molecular Mechanisms Involved in the Association Between PCOS and Endometrial and Ovarian Cancers
Zanjirband M et al. • Journal of cellular and molecular medicine (2024)
Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
- Polycystic ovary syndrome (PCOS), a major cause of female infertility, affects 4%-20% of reproductive-age women.
- Salusin-β serum levels in individuals with PCOS were identified as a potential biomarker for increased risk of OVCA.
- Gene signature-based drug repositioning identified several drug candidates: metformin, fenofibrate, fatostatin, melatonin, resveratrol and quercetin, some already established and prescribed for PCOS.
Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review
Inchingolo AD et al. • Nutrients (2022)
The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
- The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis.
- Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration.
- According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies.
Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials
Sahebkar A • Critical reviews in food science and nutrition (2017)
Available evidence from RCTs does not suggest any clinically relevant effect of quercetin supplementation on plasma lipids, apart from a significant reduction of triglycerides at doses above 50 mg/day.
- Combined estimate of effect size for the impact of quercetin on plasma LDL-C (WMD: 1.43 mg/dL, 95% CI: -0.92-3.78, p = 0.23), HDL-C (WMD: 0.26 mg/dL, 95% CI: -0.74-1.25, p = 0.61) and triglycerides (WMD: -9.42 mg/dL, 95% CI: -27.80-8.96, p = 0.32) was not statistically significant.
- However, a borderline significant but clinically non-relevant increase in total cholesterol was observed (WMD: 3.13 mg/dL, 95% CI: -0.01-6.27, p = 0.05).
- Changes in plasma triglycerides, but not other indices of lipid profile, were significantly associated with quercetin dose (slope: -0.057; 95% CI: -0.103 to -0.010; p = 0.02) and duration of supplementation (slope: -5.314; 95% CI: -9.482 to -1.147; p = 0.01).
Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis
Su P et al. • Reproductive biology and endocrinology : RB&E (2024)
This meta-analysis suggested that quercetin has positive effects on PCOS treatment.
- This meta-analysis suggested that quercetin has positive effects on PCOS treatment.
- Quercetin can systematically reduce insulin, blood glucose, cholesterol, and triglyceride levels in metabolic pathways.
- In the endocrine pathway, quercetin can regulate the function of the pituitary-ovarian axis, reduce testosterone and luteinizing hormone (LH) levels, and lower the ratio of LH to follicle-stimulating hormone (FSH).
Engineered production of bioactive polyphenolic O-glycosides
Ren J et al. • Biotechnology advances (2023)
All rights reserved.
- In this review, we systematically review and summarize the representative polyphenolic O-glycosides with various bioactivities and their engineered biosynthesis in microbes with different biotechnological strategies.
- We also review the major routes towards NDP-sugar formation in microbes, which is significant for producing unusual or novel glycosides.
- Finally, we discuss the trends in NDP-sugar based glycosylation research to promote the development of prodrugs that positively impact human health and wellness.Copyright © 2023 Elsevier Inc.