Pterostilbene Research
41 peer-reviewed studies · Evidence score: 7/10
Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions
Lin R et al. • Pharmacological research (2025)
All rights reserved.
- This review aims to provide a theoretical framework and translational guidance for developing HF-targeted therapeutic strategies based on Sirtuin-mediated macrophage polarization, as well as for the research and development of related natural products.Copyright © 2025 The Authors.
- Published by Elsevier Ltd..
- All rights reserved.
Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging
Afzal M et al. • Inflammopharmacology (2025)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
- It also examines how nanotechnology and EV strategies can help renew aging chondrocytes.
- This review examines the impact of cartilage changes on the aging process.
- It offers guidance on delaying osteoarthritis, identifies early indicators, and proposes innovative treatments to maintain joint health as grow older.© 2025.
Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms
Zhou DD et al. • Sub-cellular biochemistry (2024)
The Author(s), under exclusive license to Springer Nature Switzerland AG.
- The anti-ageing mechanisms of resveratrol and its analogues are complex and multifactorial, involving suppressing oxidative stress, ameliorating inflammation, activating SIRT1 pathway, reducing DNA damage, etc.
- In this chapter, the anti-ageing effects of resveratrol and its analogues are summarised with special attention paid to the underlying mechanisms.
- Further understanding of these small molecules could provide the necessary scientific basis for their development into anti-ageing agents.© 2024.
The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors
Nowacka A et al. • International journal of molecular sciences (2024)
The multifaceted nature of resveratrol's biological effects, including its influence on diverse physiological processes, underscores its potential as a valuable therapeutic option for the treatment of central nervous system tumors.
- The diverse biological actions of resveratrol extend beyond these well-established properties.
- It also exerts a significant impact on metabolic processes and bioavailability, and critically, it demonstrates the ability to effectively traverse the blood-brain barrier.
- The multifaceted nature of resveratrol's biological effects, including its influence on diverse physiological processes, underscores its potential as a valuable therapeutic option for the treatment of central nervous system tumors.
Antiobesity pathways of pterostilbene and resveratrol: a comprehensive insight
Özyalçın B et al. • Critical reviews in food science and nutrition (2024)
However, optimal dose, duration, mechanism, long-term safety, side effects, combination, elucidation of genomic interactions, and lifestyle modifications should be considered.
- Stilbenes are products of the plant phenylpropanoid pathway.
- Very important mechanisms for the anti-obesity impact belonging to resveratrol as well as pterostilbene include thermogenic activation in brown adipose tissue alongside the browning of white adipose tissue.
- Considering nutrition and dietary habits, which have an important place in lifestyle changes for both the prevention and the treatment of obesity, pterostilbene and resveratrol, which are polyphenols and stilbenes, are seen as promising.
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
Freeberg KA et al. • The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
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- Limitations are identified and future research directions are suggested to further our understanding of the potential efficacy of NAD+-boosting compounds for improving physiological function and extending human health span.© The Author(s) 2023.
- Published by Oxford University Press on behalf of The Gerontological Society of America.
- All rights reserved.
Pterostilbene: a potential therapeutic agent for fibrotic diseases
Wang W et al. • Inflammopharmacology (2024)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
- Fibrosis is a prevailing pathology in chronic diseases and accounts for 45% of deaths in developed countries.
- As a result, PTS has the potential to prevent and cure numerous diseases.
- In this review, we comprehensively summarize the antifibrotic effects of PTS both in vivo and in vitro and the pharmacological mechanisms, pharmacokinetics, and toxicology of PTS and provide insights into and strategies for exploring promising agents for the treatment of fibrosis.© 2024.
Research progress on inhibitors and inhibitory mechanisms of mycotoxin biosynthesis
Li M et al. • Mycotoxin research (2024)
The Author(s) under exclusive licence to Society for Mycotoxin (Research Gesellschaft für Mykotoxinforschung e.V.) and Springer-Verlag GmbH Germany, part of Springer Nature.
- It has been found that many traditionally synthesized and natural compounds are capable of inhibiting the growth of fungi and their secondary metabolite production.
- Natural compounds have attracted much attention due to their safety, environmental, and health friendly features.
- The Author(s) under exclusive licence to Society for Mycotoxin (Research Gesellschaft für Mykotoxinforschung e.V.) and Springer-Verlag GmbH Germany, part of Springer Nature.
Therapeutic application of natural products: NAD(+) metabolism as potential target
Guo C et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD+ metabolism, as well as the recent advances in the therapeutic application of natural products targeting NAD+ metabolism, with the aim to provide new insights into the treatment of multiple disorders.
- Systematic review examining Pterostilbene efficacy
- Published in Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
- Further research warranted to confirm findings
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
Zhang Q et al. • Journal of advanced research (2021)
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
- Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
- We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
- Further research warranted to confirm findings
Gene expression profiles in sporadic ALS fibroblasts define disease subtypes and the metabolic effects of the investigational drug EH301
Fels JA et al. • Human molecular genetics (2022)
For Permissions, please email: journals.permissions@oup.com.
- In conclusion, multiomic analyses highlighted the differential metabolic and transcriptomic profiles in patient-derived fibroblast sALS, which translate into differential responses to the investigational drug EH301.© The Author(s) 2022.
- Published by Oxford University Press.
- All rights reserved.
Biological Activities of Stilbenoids
Akinwumi BC et al. • International journal of molecular sciences (2018)
Therefore, further research is warranted to evaluate the salutary effects of various stilbenoids.
- Although positive results were obtained in most cell culture and animal studies, further human studies are needed to substantiate beneficial effects of stilbenoids.
- Resveratrol remains the most widely studied stilbenoid.
- However, there is limited information regarding the potential of less common stilbenoids.
Pterostilbene: Biomedical applications
Estrela JM et al. • Critical reviews in clinical laboratory sciences (2013)
Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
- Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed.
- This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol.
- Potential benefits of using combinations of different polyphenols are considered.
Chemistry of Pterostilbene and Its Metabolic Effects
Kim H et al. • Journal of agricultural and food chemistry (2020)
This systematic-review examined the effects of Pterostilbene.
- Many of the extensive studies on the potential health benefits of pterostilbene were conducted by Dr.
- Agnes Rimando, a scientist with the United States Department of Agriculture, in collaboration with many U.S. and other international research groups.
- This review highlights the pterostilbene research of Dr.
Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene
Lin WS et al. • Journal of agricultural and food chemistry (2020)
We also summarize recent research on pterostilbene's anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management.
- In this review, we illustrate that pterostilbene is a natural compound having bioavailability.
- The extensive metabolism of pterostilbene will be discussed.
- We also summarize recent research on pterostilbene's anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management.
Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease
Anlu W et al. • Pharmacological research (2019)
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- Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia.
- In this review, we focus on the relationship between the microbiota-metabolism-immunity (MMI) axis and CVD (including its risk factors) and the beneficial effects of HM to regulate this crosstalk.
- The insights may redefine our understanding of how HM works and spark a revolution in HM-based drug discovery.Copyright © 2019 Elsevier Ltd.
Effect of resveratrol and pterostilbene on aging and longevity
Li YR et al. • BioFactors (Oxford, England) (2018)
Overall, we describe resveratrol and pterostilbene potential for prevention or treatment of several age-related diseases by modulating age-related mechanisms. © 2017 BioFactors, 44(1):69-82, 2018.© 2017 International Union of Biochemistry and Molecular Biology.
- In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets.
- Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged-related disease, and health maintenance.
- Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders.
Resveratrol, pterostilbene, and dementia
Lange KW et al. • BioFactors (Oxford, England) (2018)
Future clinical trials should be conducted with long-term exposure to preparations of resveratrol and pterostilbene with high bioavailability. © 2017 BioFactors, 44(1):83-90, 2018.© 2017 International Union of Biochemistry and Molecular Biology.
- In comparison to resveratrol, pterostilbene appears to be more effective in combatting brain changes associated with aging.
- This may be attributed to the more lipophilic nature of pterostilbene with its two methoxyl groups compared with the two hydroxyl groups of resveratrol.
- The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects.
Metabolism and pharmacokinetics of resveratrol and pterostilbene
Wang P et al. • BioFactors (Oxford, England) (2018)
As a contribution to clarify and compare aspects like metabolic stability and pharmacokinetics of resveratrol and pterostilbene, as well as explain the pharmacological similarities and differences between them, this review presents and compares recent data on the metabolism and pharmacokinetics of resveratrol and pterostilbene. © 2018 BioFactors, 44(1):16-25, 2018.© 2018 International Union of Biochemistry and Molecular Biology.
- Resveratrol and pterostilbene exhibit many pharmacological similarities and both of them are generally considered to be safe for human consumption.
- Beyond the structural and general bioactivity similarities between them, large amounts of data are now available to reveal the metabolic fate and pharmacological differences between them.
- Further research warranted to confirm findings
[Emerging Actions of Pterostilebene on Cancer Research]
Zhang X et al. • Zhongguo fei ai za zhi = Chinese journal of lung cancer (2018)
Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms. .
- Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene) is a polyphenolic compound primarily found in blueberries, grapes, and a tree wood, pterocarpus marsupium.
- Studies demonstrate that pterostilbene inhibits a variety of cancers, such as lung, breast, stomach, colon, etc.
- The anti-cancer activities are related to the regulation of several hallmarks of cancer.