Phosphatidylserine Research
41 peer-reviewed studies · Evidence score: 8.5/10
Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis
Zhou P et al. • PloS one (2024)
The rankings of safety and efficacy of the 12 antioxidants vary.
- The rankings of safety and efficacy of the 12 antioxidants vary.
- Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
- More high-quality studies are still needed to verify our findings.
Prevalence of aPhosphatidylserine/prothrombin antibodies and association with antiphospholipid antibody profiles in patients with antiphospholipid syndrome: A systematic review and meta-analysis
Zhu R et al. • Thrombosis research (2022)
These data show a high rate of aPS/PT positivity in patients with APS (especially in those positive for LAC) but further studies are needed to ascertain whether this test might be useful in the laboratory classification criteria of APS.
- Pooled prevalence of aPS/PT IgG alone, IgM alone, and IgG/M were 50.0%, 45.0%, and 65.0%, respectively.
- When the prevalence of aPS/PT was calculated in homogeneous aPLs, a much higher rate of pooled prevalence of aPS/PT IgG/M in patients positive for Lupus Anticoagulant (84.5%) and in those with triple positivity (83.4%) was found.
- These data show a high rate of aPS/PT positivity in patients with APS (especially in those positive for LAC) but further studies are needed to ascertain whether this test might be useful in the laboratory classification criteria of APS.
Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review
Sciascia S et al. • Thrombosis and haemostasis (2014)
Their inclusion as laboratory criteria for the APS should be indisputably further explored.
- This systematic review is based on available data from more than 7,000 patients and controls from 38 studies analysing aPT and 10 aPS/PT.
- In conclusion, routine measurement of aPS/PT (but not aPT) might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or systemic lupus erythematosus.
- Their inclusion as laboratory criteria for the APS should be indisputably further explored.
Neuronutrients and Central Nervous System: A Systematic Review
Nogueira-de-Almeida CA et al. • Central nervous system agents in medicinal chemistry (2023)
The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases.
- According to the GRADE instrument, most studies (>50%) followed a controlled clinical study model and had a good methodological design.
- The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases.
- The recognition of the role of nutrition as an adjunct to these processes is currently growing.
Prognostic potential of lipid profiling in cancer patients: a systematic review of mass spectrometry-based studies
Takanashi Y et al. • Lipids in health and disease (2024)
This systematic-review examined the effects of Phosphatidylserine.
- In conclusion, the potential for developing lipidomics in cancer prognostic prediction was demonstrated.
- However, the field is still nascent, necessitating future studies for validating and establishing lipid markers as reliable prognostic tools in clinical practice.© 2024.
- Further research warranted to confirm findings
Phosphatidylserine and cognitive function
Glade MJ, Smith K • Nutrition (2015)
Phosphatidylserine supplementation supports cognitive functions that decline with age.
- Supports memory in age-related decline
- Improves attention and concentration
- Safe for long-term use
Prevalence of antiphospholipid antibodies in COVID-19 patients: A meta-analysis
Jin E et al. • Vascular pharmacology (2025)
The prevalence of aPL in COVID-19 patients was significantly higher than in the healthy control group.
- Anti-β2GP1 IgA antibodies were the most common aPL in COVID-19 patients, with a significantly higher prevalence than in the healthy group (RR = 4.26, 95 % CI = 2.84-6.40, P < 0.00001).
- The prevalence of aPL in COVID-19 patients was significantly higher than in the healthy control group.
- IgM aPL was more easily detectable in the early stages of COVID-19 infection, while IgG aPL may be of more concern in the later time points of the immune epidemiology following SARS-CoV-2 infection.
Presence of antiphospholipid antibodies is associated with increased implantation failure following in vitro fertilization technique and embryo transfer: A systematic review and meta-analysis
Papadimitriou E et al. • PloS one (2022)
The prevalence of antiphospholipid antibodies, particularly that of anti-beta2 glycoprotein-I and anti-phosphatidylserine antibodies, in women experiencing at least two implantation failures in IVF-ET without diagnosis of antiphospholipid syndrome is significantly greater than either in women who had a successful implantation after IVF-ET or women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET.
- Meta-analysis examining Phosphatidylserine efficacy
- Published in PloS one (2022)
- Further research warranted to confirm findings
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Bruton A et al. • Journal of alternative and complementary medicine (New York, N.Y.) (2021)
Conclusions: Preliminary evidence suggests that phosphatidylserine may be effective for reducing symptoms of inattention in children with ADHD, although the quality of the evidence is low and additional research in this area is warranted.
- Standardized mean differences and 95% confidence intervals (CIs) were calculated, and the heterogeneity of the studies was estimated using I2.
- Results of the meta-analysis showed a statistically significant effect of 200-300 mg/day of phosphatidylserine on symptoms of inattention relative to placebo (effect size [ES] 0.36; 95% CI: 0.07 to 0.64; p = 0.01).
- The effects of phosphatidylserine on overall symptoms of ADHD (ES 0.76; 95% CI: -0.07 to 1.60; p = 0.07) and hyperactivity-impulsivity (ES 0.24; 95% CI: -0.04 to 0.53; p = 0.09) were not statistically significant.
Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review
Yang Z et al. • European journal of medical research (2022)
This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
- This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
- Published in European journal of medical research (2022)
- Further research warranted to confirm findings
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Duan H et al. • Journal of affective disorders (2025)
This food supplement containing phosphatidylserine could improve different cognitive functions of MCI patients, especially short-term memory, and increase serum n-3 PUFAs and neurotransmitters levels.
- A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group (n = 95) and intervention group (n = 95).
- Compared with placebo group, the intervention group had statistically significant improvements in arithmetic testing (β, 0.688; 95 % CI, 0.103-1.274), the similarity test (β, 1.070; 95 % CI, 0.472-1.667) and short-term memory (β, 0.600; 95 % CI, 0.399-0.800).
- And the intervention may improve short-term memory by increasing serum ALA levels (average causal mediation effect = 0.132, 95 % CI, 0.053-0.225) with 19.7 % mediation proportion.
Tie2 protects the vasculature against thrombus formation in systemic inflammation
Higgins SJ et al. • The Journal of clinical investigation (2018)
Finally, interventions targeting Tie2 may normalize coagulation in inflammatory states while averting the bleeding risks of current DIC therapies.
- Conversely, Tie2 activation normalized prothrombotic responses by inhibiting endothelial tissue factor and phosphatidylserine exposure.
- Critically, Tie2 activation had no adverse effects on bleeding.
- These results mechanistically implicate Tie2 signaling as a central regulator of microvascular thrombus formation in septic DIC and indicate that circulating markers of the Tie2 axis could facilitate earlier diagnosis.
Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial
Tian Z et al. • Nutrients (2022)
The results suggest that WSTC can inhibit oxidative stress and its related platelet apoptosis, which may provide a basis for the primary prevention of WSTC in ASCVD.
- The results showed that WSTC could increase the serum total antioxidant capacity levels (p < 0.05) and decrease the serum malondialdehyde levels (p < 0.05) after a 4-week WSTC supplementation in healthy middle-aged and elderly adults.
- Platelet endogenous reactive oxygen species generation (p < 0.05), mitochondrial membrane potential dissipation (p < 0.05) and phosphatidylserine exposure (p < 0.05) were attenuated.
- In addition, our present study also found that WSTC could inhibit platelet aggregation and activation induced by collagen or ADP after intervention (p < 0.05), while having no effects on adverse events (p > 0.05).
Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel
Youngblood MW et al. • Nature communications (2025)
This rct examined the effects of Phosphatidylserine.
- Thus, our study introduces an efficient microfluidic platform for the capture of circulating GBM EVPs and demonstrates that release upon BBB opening is predictive of outcomes following paclitaxel treatment.
- This approach represents a real-time surrogate biomarker for treatment response for a disease where imaging-based assessment of response has not been shown to be reliable.
- Future prospective validation is warranted.© 2025.
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial
Hsiehchen D et al. • Nature communications (2024)
This rct examined the effects of Phosphatidylserine.
- Among 28 evaluable patients, the confirmed response rate was 32.1%, which met the pre-specified endpoint, and the median progression-free survival was 6.3 months (95% CI, 1.3-11.3 months).
- Treatment related-adverse events of any grade occurred in 45.7% of patients, with grade 3 or greater adverse events in 14.3% of patients.
- Adverse events of any cause were observed in 33 patients (94.3%), with grade 3 or greater adverse events in 11 patients (31.4%).
Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial
Ramberg C et al. • Journal of thrombosis and haemostasis : JTH (2022)
Rosuvastatin treatment caused a substantial decrease in plasma PPL activity, suggesting that a PPL-dependent attenuation of coagulation activation may contribute to a reduced VTE risk following statin treatment.
- Rosuvastatin treatment yielded an overall 22% (95% confidence interval [CI] -38.2 to -5.8) reduction in PPL activity, and 37% (95% CI -62.9 to -11.2) reduction in PPL activity in participants with a history of pulmonary embolism.
- Rosuvastatin treatment caused a substantial decrease in plasma PPL activity, suggesting that a PPL-dependent attenuation of coagulation activation may contribute to a reduced VTE risk following statin treatment.
- Further research warranted to confirm findings
Responses of the Serum Lipid Profile to Exercise and Diet Interventions in Nonalcoholic Fatty Liver Disease
Qi Z et al. • Medicine and science in sports and exercise (2024)
Changes of lipidome after exercise and/or diet interventions were associated with HFC reductions, which are independent of visceral fat reduction, particularly in metabolites belonging to PC.
- Changes of lipidome after exercise and/or diet interventions were associated with HFC reductions, which are independent of visceral fat reduction, particularly in metabolites belonging to PC.
- Importantly, baseline PE could predict the HFC response to exercise, and PC predicted the response to diet.
- These results indicate that a circulating metabolomics panel can be used to facilitate clinical implementation of lifestyle interventions for NAFLD management.
Phosphatidylserine enriched with polyunsaturated n-3 fatty acid supplementation for attention-deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo-controlled trial
Rheims S et al. • Epilepsia open (2024)
Our study remaining underpowered, no formal conclusion about the effect of Ps-Omega3 could be drawn.
- The reduction after 12 weeks of treatment in the inattention subscore of the ADHD-IV scale was -1.57 in the PS-Omega3 group, and -2.90 in the placebo group (p = 0.33, α = 5%).
- Our study remaining underpowered, no formal conclusion about the effect of Ps-Omega3 could be drawn.
- However, our data strongly suggested that the PS-Omega 3 formulation used in the current study did not improve ADHD symptoms in children with epilepsy.
Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study
D'Orio M et al. • Acta bio-medica : Atenei Parmensis (2023)
Dietary integration could be considered as an option in patients who could not undergo surgery.
- Dietary integration could be considered as an option in patients who could not undergo surgery.
- Symptoms and pain could improve, but surgery remains the gold standard for recovery of function in mild to moderate CTS.
- Further research warranted to confirm findings
Lactobacillus casei modulates inflammatory cytokines and metabolites during tuberculosis treatment: A post hoc randomized controlled trial
Jiang L et al. • Asia Pacific journal of clinical nutrition (2022)
Lactobacillus casei supplementation during the intensive phase of tuberculosis treatment can significantly modulate inflammatory cytokines and metabolites.
- Daily Lactobacillus casei supplementation of up to 2 × 1010 colony-forming units significantly lowered the concentrations of tumor necrosis factor-α, interleukin-6, interleukin-10, and interleukin-12 (p=0.007, p=0.042, p=0.002, p<0.001, respectively) in patients with tuberculosis.
- Lactobacillus casei supplementation during the intensive phase of tuberculosis treatment can significantly modulate inflammatory cytokines and metabolites.
- Decreased inflammatory cytokines may be related to metabolite changes.