Pantothenic Acid Research
39 peer-reviewed studies · Evidence score: 7.5/10
Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review
Pereira F et al. • International journal of molecular sciences (2024)
However, future studies are needed to understand its biological significance in the context of BCa and to validate its clinical application.
- Urine samples displayed a higher likelihood of containing metabolites that are also present in bladder tumor tissue and cell line cultures.
- Overall, molecular profiling of biological samples by metabolomics is a promising approach to identifying potential biomarkers for early diagnosis of different BCa subtypes.
- However, future studies are needed to understand its biological significance in the context of BCa and to validate its clinical application.
Serum Metabolomic Markers of Dairy Consumption: Results from the Atherosclerosis Risk in Communities Study and the Bogalusa Heart Study
Bernard L et al. • The Journal of nutrition (2023)
We identified metabolomic associations with dietary intake of dairy, including 3 associations found in 2 independent cohort studies.
- In the ARIC study and BHS, the mean age was 54 and 48 years, 61% and 29% were Black, and the mean dairy intake was 1.7 and 1.3 servings/day, respectively.
- We identified metabolomic associations with dietary intake of dairy, including 3 associations found in 2 independent cohort studies.
- These results suggest that myristate (14:0) and pantothenate (vitamin B5) are candidate biomarkers of dairy consumption.
Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis
Shi J et al. • Annals of palliative medicine (2021)
Additionally, both the ulcer healing time [standardized mean difference (SMD) =-2.15, 95% CI: -2.80 to -1.50, P<0.001] and treatment time (SMD =-2.31, 95% CI: -2.67 to -1.96, P<0.001) in the treatment group were shorter than those of the control group.
- In comparison with the control group, the effective rate was higher [odds ratio (OR) =5.24, 95% confidence interval (CI): 3.72 to 7.37, P<0.001] while the recurrence rate was lower (OR =0.194, 95% CI: 0.128 to 0.295, P<0.001) in the treatment group.
- Additionally, both the ulcer healing time [standardized mean difference (SMD) =-2.15, 95% CI: -2.80 to -1.50, P<0.001] and treatment time (SMD =-2.31, 95% CI: -2.67 to -1.96, P<0.001) in the treatment group were shorter than those of the control group.
- Further research warranted to confirm findings
Pantethine (Active B5 Derivative) and Cardiovascular Risk Factors: A Systematic Review
Evans M et al. • Nutrition Research (2021)
Pantethine (a pantothenic acid derivative) modestly reduced total cholesterol and LDL cholesterol across trials.
- Pantethine at 600-900mg/day reduced total cholesterol by 11% and LDL by 12.5%
- Effects attributed to inhibition of hepatic cholesterol and fatty acid synthesis
- Well-tolerated across all reviewed clinical trials
Revealing VNN1: An Emerging and Promising Target for Inflammation and Redox Balance
Lv L et al. • Immunity, inflammation and disease (2025)
VNN1 represents a promising therapeutic target for modulating oxidative stress and immunometabolism in various diseases.
- VNN1 represents a promising therapeutic target for modulating oxidative stress and immunometabolism in various diseases.
- Future research should develop disease-specific inhibitors, clarify tissue-specific mechanisms, and conduct clinical trials for translation.
- Further research warranted to confirm findings
Comparative bioavailability of vitamins in human foods sourced from animals and plants
Chungchunlam SMS et al. • Critical reviews in food science and nutrition (2024)
The overview of studies showed that in general, vitamins in foods originating from animals are more bioavailable than vitamins in foods sourced from plants.
- Plant-based foods are the main natural sources of vitamin C (76% bioavailable), provitamin A carotenoid β-carotene (15.6% bioavailable), riboflavin (65% bioavailable), thiamin (81% bioavailable), and vitamin K (16.5% bioavailable).
- The bioavailability of naturally occurring choline, vitamin D, vitamin E, and vitamin K in food awaits further studies.
- The overview of studies showed that in general, vitamins in foods originating from animals are more bioavailable than vitamins in foods sourced from plants.
Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus Interventions and Supplementation-A Systematic Review
Kędzierska-Kapuza K et al. • Nutrients (2023)
Taking into account the research conducted so far, it seems that the use of vitamin supplementation in CKD patients may have a positive impact on the treatment process and maintaining a disease-free condition.
- Taking into account the research conducted so far, it seems that the use of vitamin supplementation in CKD patients may have a positive impact on the treatment process and maintaining a disease-free condition.
- Published in Nutrients (2023)
- Further research warranted to confirm findings
Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models
Nieto Ramirez LM et al. • Frontiers in immunology (2024)
Simpler, physiologically relevant, and ethically sound models, such as G. mellonella, are needed for studying innate responses in MTBC infection.
- Simpler, physiologically relevant, and ethically sound models, such as G. mellonella, are needed for studying innate responses in MTBC infection.
- While insects lack adaptive immunity, they could provide insights into "pure" innate immune responses.
- The dissection of "pure," "sustained" (later than 7 days post-infection), and trained innate immunity presents additional challenges that require high-resolution temporospatial analytical methods.
ESPEN micronutrient guideline
Berger MM et al. • Clinical nutrition (Edinburgh, Scotland) (2022)
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.
- The recommendations underwent a consensus process, which resulted in a percentage of agreement (%): strong consensus required of >90% of votes.
- This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.
- In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences
Ali MA et al. • Nutrients (2022)
More research should be invested in studying each vitamin individually concerning nutritional disparities in each life stage, with extensive attention paid to cultural differences and lifestyles.
- During infancy and childhood, B vitamins are integrated with physical and psychological development that have a pivotal impact on one's overall health in adolescence and adulthood.
- A higher intake of B vitamins in the elderly is also associated with preventing some aging problems, especially those related to inflammation.
- All supplementation should be carefully monitored to avoid toxicity and hypervitaminosis.
Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B(1), B(2), B(3), and B(5)
Hrubša M et al. • Nutrients (2022)
The article also sums up: (i) the current methods for detection of the vitamins of the B-complex in biological fluids; (ii) the food and other sources of these vitamins including the effect of common processing and storage methods on their content; and (iii) their physiological function.
- The therapeutic use of B-complex vitamins is mostly limited to hypovitaminoses or similar conditions, but, as they are generally very safe, they have also been examined in other pathological conditions.
- Nicotinic acid, a form of vitamin B3, is the only exception because it is a known hypolipidemic agent in gram doses.
- The article also sums up: (i) the current methods for detection of the vitamins of the B-complex in biological fluids; (ii) the food and other sources of these vitamins including the effect of common processing and storage methods on their content; and (iii) their physiological function.
Role of Vitamins in Neurodegenerative Diseases: A Review
Kumar RR et al. • CNS & neurological disorders drug targets (2022)
The deficiency of vitamins in the body causes various neurological disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and depression.
- The deficiency of vitamins in the body causes various neurological disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and depression.
- We have discussed the role of vitamins in neurological disorders and the normal human body.
- Depression is linked to a deficiency of vitamin-C and vitamin B.
B Vitamins and Their Role in Immune Regulation and Cancer
Peterson CT et al. • Nutrients (2020)
Much work remains to be carried out to fully clarify these relationships as the complexity of B vitamins' essential functions complicates an unequivocal assessment of their beneficial or detrimental effects in inflammation and cancers.
- More recently, another source of B vitamins has been identified which is derived from portions of the 1013 bacterial cells inhabiting the gastrointestinal tract.
- Here we review the expanding literature examining the relationship between B vitamins and the immune system and diverse cancers.
- Evidence of B vitamin's role in immune cell regulation has accumulated in recent years and may help to clarify the disparate findings of numerous studies attempting to link B vitamins to cancer development.
B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review
Kennedy DO • Nutrients (2016)
Furthermore, evidence from human research clearly shows both that a significant proportion of the populations of developed countries suffer from deficiencies or insufficiencies in one or more of this group of vitamins, and that, in the absence of an optimal diet, administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health.
- However, human epidemiological and controlled trial investigations, and the resultant scientific commentary, have focused almost exclusively on the small sub-set of vitamins (B9/B12/B6) that are the most prominent (but not the exclusive) B-vitamins involved in homocysteine metabolism.
- Scant regard has been paid to the other B vitamins.
- This review describes the closely inter-related functions of the eight B-vitamins and marshals evidence suggesting that adequate levels of all members of this group of micronutrients are essential for optimal physiological and neurological functioning.
Hass avocado composition and potential health effects
Dreher ML et al. • Critical reviews in food science and nutrition (2013)
Exploratory studies suggest that avocados may support weight management and healthy aging.
- There are eight preliminary clinical studies showing that avocado consumption helps support cardiovascular health.
- Exploratory studies suggest that avocados may support weight management and healthy aging.
- Further research warranted to confirm findings
Management of acute radiation dermatitis: A review of the literature and proposal for treatment algorithm
Rosenthal A et al. • Journal of the American Academy of Dermatology (2019)
All rights reserved.
- Radiation dermatitis is a common sequela of radiation therapy; up to 95% of patients will develop moderate-to-severe skin reactions.
- It is therefore imperative to develop a greater understanding of management options available to allow clinicians to make informed decisions when managing radiation oncology patients.
- Published by Elsevier Inc.
Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies
Zhou K et al. • Journal of thrombosis and thrombolysis (2012)
Further prospective clinical studies are needed to provide additional evidence on the clinical benefits of B-group vitamin supplementation for VT.
- Significant standardized mean differences were obtained for plasma folic acid (-0.55; 95% CI, -0.75 to -0.36) and vitamin B12 (-0.34; 95% CI, -0.55 to -0.13).
- Moreover, a qualitative systematic review indicated that low level of vitamin B6 was an independent risk factor of VT.
- Randomized clinical studies of B-group vitamins supplementation showed varying results on VT prevention.
Intestinal absorption of water-soluble vitamins in health and disease
Said HM • The Biochemical journal (2011)
The present review aims to outline our current understanding of the mechanisms involved in intestinal absorption of water-soluble vitamins, their regulation, the cell biology of the carriers involved and the factors that negatively affect these absorptive events.© The Authors Journal compilation © 2011 Biochemical Society
- These processes are regulated by a variety of factors and conditions, and the regulation involves transcriptional and/or post-transcriptional mechanisms.
- Also well recognized now is the fact that the large intestine possesses specific and efficient uptake systems to absorb a number of water-soluble vitamins that are synthesized by the normal microflora.
- This source may contribute to total body vitamin nutrition, and especially towards the cellular nutrition and health of the local colonocytes.
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism
Depeint F et al. • Chemico-biological interactions (2006)
The effectiveness of B vitamins as antioxidants preventing oxidative stress toxicity is also reviewed.
- Biotin (B7) is the coenzyme of decarboxylases required for gluconeogenesis and fatty acid oxidation.
- Pyridoxal (B6), folate and cobalamin (B12) properties are reviewed elsewhere in this issue.
- The experimental animal and clinical evidence that vitamin B therapy alleviates B deficiency symptoms and prevents mitochondrial toxicity is also reviewed.
Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial
Fukatsu K et al. • Annals of nutrition & metabolism (2022)
Blood vitamin levels decreased when patients were administered PPN without vitamin supplementation during the first week after surgery.
- Blood vitamin levels decreased when patients were administered PPN without vitamin supplementation during the first week after surgery.
- The novel PPN formula containing multivitamins recommended by FDA2000 can be safely administered to postoperative patients to maintain blood vitamin levels.
- Further research warranted to confirm findings