Manganese Research
40 peer-reviewed studies · Evidence score: 7.5/10
Association of Blood Manganese and Preeclampsia: A Systematic Review and Meta-analysis
Wu A et al. • Biological trace element research (2024)
The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Pooled results showed that compared to normotensive control, women with PE had significantly lower blood Mn concentration (standardized mean difference: -0.36, 95% confidence interval: -0.50 to -0.22, p < 0.001; I2 = 67%).
- Finally, pooled results of three studies showed that a high level of blood Mn was related to a low risk of PE with blood Mn analyzed in continuous (risk ratio [RR]: 0.71, 95% CI: 0.59 to 0.85, p < 0.001; I2 = 0%) and categorized variables (RR: 0.50, 95% CI: 0.30 to 0.82, p = 0.006; I2 = 32%).
- In conclusion, a low blood level of Mn may be associated with PE in pregnant women.© 2023.
Change in Mineral Status After Bariatric Surgery: a Meta-analysis
Cao L et al. • Obesity surgery (2023)
A high deficiency rate of serum iron, zinc, copper, chlorine, phosphorus, and calcium was seen after bariatric surgery.
- The most severe mineral deficiency after bariatric surgery was iron (20.1%), followed by zinc (18.3%), copper (14.4%), chlorine (12.2%), phosphorus (7.5%), and calcium (7.4%).
- The difference in surgical procedures, study regions, and follow-up time may affect postoperative mineral status; more targeted mineral supplement programs are needed considering these influencing factors.
- Further research warranted to confirm findings
Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review
Woolhiser E et al. • JMIR dermatology (2024)
This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for seborrheic dermatitis.
- Seborrheic dermatitis was correlated with significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations.
- This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for seborrheic dermatitis.
- The negative consequences of a Western diet, alcohol use, obesity, and the benefits of fruit consumption are well known; however, to fully understand their specific relationships to seborrheic dermatitis, further cohort or interventional studies are needed.
A systematic review and meta-analysis of the hyperuricemia risk from certain metals
Gu T et al. • Clinical rheumatology (2022)
The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
- Data were pooled by random-effects models and expressed as pooled odds ratios (OR) and 95% confidence intervals (CIs).
- Exposure to molybdenum (pooled OR = 0.804, 0.724, 0.975, 3, 0%) was linked to a decreased risk of HUA, however.
- Molybdenum exposure was associated with a decreased prevalence of HUA; however, aluminum, cobalt, copper, iron, magnesium, manganese, mercury, selenium, thallium and zinc are not associated with HUA risk.
Mushroom Consumption and Cardiovascular Health: A Systematic Review
Krittanawong C et al. • The American journal of medicine (2021)
Edible mushroom consumption has not been shown to conclusively affect cardiovascular risk factors to date.
- Edible mushroom consumption has not been shown to conclusively affect cardiovascular risk factors to date.
- However, potential health benefits may exist, including a favorable alteration of lipid profiles and blood pressure reduction.
- Further research warranted to confirm findings
Blood Trace Element Status in Multiple Sclerosis: a Systematic Review and Meta-analysis
Nirooei E et al. • Biological trace element research (2022)
The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
- Weighted mean differences (WMDs) and corresponding 95% CI were considered as a pooled effect size (ES).
- Pooled results using random-effects model indicated that the levels of Zn (WMD = - 7.83 mcg/dl, 95% CI = - 12.78 to - 2.87, Z = 3.09, P = 0.002), and Fe (WMD = - 13.66 mcg/dl, 95% CI = - 23.13 to - 4.19, Z = 2.83, P = 0.005) were significantly lower in MS patients than in controls.
- However, it was found that levels of Mn (WMD = 0.03 mcg/dl, 95% CI = 0.01 to 0.04, Z = 2.89, P = 0.004) were significantly higher in MS patients.
Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease
Newell ME et al. • The Science of the total environment (2022)
Published by Elsevier B.V.
- Two orthogonal methods employed implicate BMAA, formaldehyde, manganese, mercury, and zinc as environmental factors with strong ALS associations.
- ALS cases likely are significantly underreported globally, and high vulnerability exists in regions with large aging populations.
- Recent studies on other diseases with environmental determinants suggest the need to consider additional potential triggers and mechanisms, including exposures to microbial agents and epigenetic modifications.Copyright © 2021.
Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis
Liu W et al. • Environmental health : a global access science source (2020)
Higher manganese exposure is adversely associated with childhood neurodevelopment.
- The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), - 4.58, - 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects.
- Higher manganese exposure is adversely associated with childhood neurodevelopment.
- Hair is the most reliable indicator of manganese exposure for children at 6-18 years of age.
Dietary Manganese Intake and Risk of Metabolic Syndrome: A Meta-Analysis of Observational Studies
Du S, Wu X, Han T, Duan W, Liu L, Qi J, Niu Y, Na L, Sun C • Nutrients (2018)
Higher dietary manganese intake was inversely associated with metabolic syndrome risk.
- Higher manganese intake associated with 17% lower risk of metabolic syndrome
- Inverse association with fasting blood glucose levels
- Dose-response relationship observed across included studies
Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis
Li K et al. • Environmental pollution (Barking, Essex : 1987) (2023)
All rights reserved.
- In a further meta-analysis, standardized mean differences (SMDs) of 13 elements were calculated to evaluate their altered in AD patients, including copper, iron, zinc, selenium, manganese, lead, aluminum, cadmium, chromium, arsenic, mercury, cobalt, and manganese.
- We identified four trace elements-copper (serum), iron (plasma), zinc (hair), and selenium (plasma)-altered in AD patients, with SMDs of 0.37 (95% confidence interval [CI]: 0.10, 0.65), -0.68 (95% CI: -1.34, -0.02), -0.35 (95% CI: -0.62, -0.08), and -0.61 (95% CI: -0.97, -0.25), respectively.
- Finally, we formed a database of various trace element levels in AD patients and healthy controls.
Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study
Shi H et al. • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2024)
The study suggests that there is an association between the occurrence of OA and variations in serum levels of copper, manganese, cadmium, and selenium.
- The study suggests that there is an association between the occurrence of OA and variations in serum levels of copper, manganese, cadmium, and selenium.
- Elevated serum copper may play a pivotal role.
- Further research is needed to explore the therapeutic potential of TE level modulation in OA management.
Exposure to metal mixtures and adverse pregnancy and birth outcomes: A systematic review
Issah I et al. • The Science of the total environment (2024)
In conclusion, this review consistently establishes connections between metal exposure during pregnancy and adverse consequences for birth weight, gestational age, and other vital birth-related metrics.
- In conclusion, this review consistently establishes connections between metal exposure during pregnancy and adverse consequences for birth weight, gestational age, and other vital birth-related metrics.
- This review further demonstrates the need to apply mixture methods with caution but also shows that they can be superior to traditional approaches.
- Further research is warranted to deeper understand the underlying mechanisms and to develop effective strategies for mitigating the potential risks associated with metal mixture exposure during pregnancy.
Micronutrients and Androgenetic Alopecia: A Systematic Review
Wang R et al. • Molecular nutrition & food research (2024)
Deficiencies or imbalances in specific vitamins and minerals, especially vitamin B, vitamin D, Fe, Se, and Zn are involved in the pathogenesis of AGA and may represent modifiable risk factors for the treatment and prevention of this condition.
- Deficiencies or imbalances in specific vitamins and minerals, especially vitamin B, vitamin D, Fe, Se, and Zn are involved in the pathogenesis of AGA and may represent modifiable risk factors for the treatment and prevention of this condition.
- Published in Molecular nutrition & food research (2024)
- Further research warranted to confirm findings
Manganese-derived biomaterials for tumor diagnosis and therapy
Huang P et al. • Journal of nanobiotechnology (2024)
This systematic-review examined the effects of Manganese.
- Moreover, the advantages of Mn-based materials in tumor treatment applications are discussed, including drug delivery, tumor microenvironment regulation, synergistic photothermal, photodynamic, and chemodynamic therapies, tumor immunotherapy, and imaging-guided therapy.
- The review concludes by providing insights into the current landscape and future directions for Mn-driven advancements in the field, serving as a comprehensive resource for researchers and clinicians.© 2024.
- Further research warranted to confirm findings
The preventive and carcinogenic effect of metals on cancer: a systematic review
Khoshakhlagh AH et al. • BMC public health (2024)
Metals have carcinogenic effects at high levels of exposure.
- Metals have carcinogenic effects at high levels of exposure.
- Taking preventive measures, implementing timely screening, and reducing the emission of metal-associated pollutants can play an effective role in reducing cancer rates around the world.
- Further research warranted to confirm findings
Salivary elemental signature of dental caries: a systematic review and meta-analysis of ionomics studies
Alqahtani AA et al. • Odontology (2024)
The Author(s), under exclusive licence to The Society of The Nippon Dental University.
- Half of the included studies (17/34) were considered high quality, while the remaining half were considered medium quality.
- Only zinc and chloride ions were found to be higher significantly and consistent in CF and CA subjects, respectively.
- Conflicting outcomes were observed for all other salivary chemical elements including aluminum, bromine, calcium, copper, fluoride, iron, potassium, magnesium, manganese, sodium, ammonia, nitrite, nitrate, phosphorus, lead, selenium, and sulfate ions.© 2023.
Blood manganese level and gestational diabetes mellitus: a systematic review and meta-analysis
Sun Y et al. • Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2023)
Results of the meta-analysis suggest that a high blood Mn level may be a risk factor of GDM in pregnant women.
- Among the participants, 3597 (3.9%) were diagnosed as GDM.
- Results of the meta-analysis suggest that a high blood Mn level may be a risk factor of GDM in pregnant women.
- Studies are needed to determine the underlying mechanisms, and to investigate if the relationship between blood Mn level and GDM is dose-dependent.
Occupational Exposure to Metal Fumes Among Iranian Welders: Systematic Review and Simulation-Based Health Risk Assessment
Soltanpour Z et al. • Biological trace element research (2023)
The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
- Cancer risk due to exposure to nickel in both gas and arc welding was probable (1 × 10-6 < cancer risk (CR) < 1 × 10-4).
- Health risk assessment showed that welders are exposed to health risks.
- Preventive measures should be applied in welding workplaces to reduce the concentrations of metal fumes.© 2022.
ESPEN micronutrient guideline
Berger MM et al. • Clinical nutrition (Edinburgh, Scotland) (2022)
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.
- The recommendations underwent a consensus process, which resulted in a percentage of agreement (%): strong consensus required of >90% of votes.
- This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.
- In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Interaction between selenium and essential micronutrient elements in plants: A systematic review
Gui JY et al. • The Science of the total environment (2022)
Published by Elsevier B.V.
- The regulatory mechanisms of Se on these micronutrients are also analyzed.
- Based on the current understanding of the interaction between Se and these essential elements, future directions for research are suggested.Copyright © 2022.
- Published by Elsevier B.V.