Hesperidin Research
47 peer-reviewed studies · Evidence score: 7.5/10
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials
Long Z et al. • Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
- Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
- However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
- Further research warranted to confirm findings
Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis
Yang K et al. • Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
- Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
- For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
- Further research warranted to confirm findings
Hesperidin reduces systolic blood pressure in diabetic patients and has no effect on blood pressure in healthy individuals: A systematic review and meta-analysis
Gao H et al. • Phytotherapy research : PTR (2024)
The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.© 2024 John Wiley & Sons Ltd.
- The results of total population blood pressure showed that hesperidin had no antihypertensive effect on the population, but the conclusions changed when the population was divided into groups.
- The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.© 2024 John Wiley & Sons Ltd.
- Further research warranted to confirm findings
The effects of hesperidin supplementation or orange juice consumption on anthropometric measures in adults: A meta-analysis of randomized controlled clinical trials
Djafari F et al. • Clinical nutrition ESPEN (2021)
The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures.
- The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures.
- The authors advocate that more high-quality clinical trials are needed to better discern the potential efficacy of orange juice and/or hesperidin.
- Further research warranted to confirm findings
Drug delivery and formulation development of hesperidin: a systematic review
Hoang TPN et al. • Expert opinion on drug delivery (2026)
Formulation advances can significantly mitigate hesperidin's biopharmaceutical liabilities, with lipid-based systems, polymeric nanoparticles, and phytosomes emerging as leading strategies.
- Formulation advances can significantly mitigate hesperidin's biopharmaceutical liabilities, with lipid-based systems, polymeric nanoparticles, and phytosomes emerging as leading strategies.
- Translation will benefit from stability and immunotoxicity packages, quality-by-design manufacturing, and well-designed, adequately powered clinical trials using harmonised pharmacokinetic and clinical endpoints.
- Further research warranted to confirm findings
Hesperidin for chronic venous insufficiency
Martinez-Zapata MJ et al. • Cochrane Database of Systematic Reviews (2020)
Phlebotonics (including hesperidin) reduced edema, pain, and other symptoms of chronic venous insufficiency.
- Reduced leg edema
- Improved symptoms
- Generally well-tolerated
Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials
Mohammadi M et al. • Phytotherapy research : PTR (2019)
Future well-designed trials are still needed to confirm these results.© 2019 John Wiley & Sons, Ltd.
- Effect sizes were pooled by using the random effects model.
- Hesperidin supplement also had no effect on systolic (WMD = -0.85 mmHg; 95% CI [-3.07, 1.36]) and diastolic blood pressure (WMD = -0.48 mmHg; 95% CI [-2.39, 1.42]).
- Hesperidin supplementation might not improve lipid profile and blood pressure.
Efficacy and molecular mechanisms of hesperidin in mitigating Alzheimer's disease: A systematic review
Han X et al. • European journal of medicinal chemistry (2025)
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- Few clinical trials have indicated that dietary supplements rich in hesperidin can improve cerebral blood flow, cognition, and memory performance.
- The neuroprotective effect of hesperidin may be exerted via regulating different molecular pathways, including the RAGE/NF-κB, Akt/Nrf2, and AMPK/BDNF/CREB pathways.
- However, further clinical trials are needed to confirm the neuroprotective effects of this natural flavonoid compound and to assess its safety.Copyright © 2024 Elsevier Masson SAS.
Supplementation with antioxidants and phenolic compounds in ruminant feeding and its effect on dairy products: a systematic review
Avila-Nava A et al. • The Journal of dairy research (2023)
In conclusion, supplementation with bioactive compounds had a positive impact which ranged from an increase in antioxidant capacity to a decrease in oxidative biomarkers such as malondialdehyde.
- Of the 94 studies identified in the search, only 15 met the inclusion criteria and were analyzed.
- In six studies, the addition of Acacia farnesiana, hesperidin or naringin, durum wheat bran, mushroom myceliated grains, dried grape pomace and olive leaves increased the antioxidant activity of milk.
- In conclusion, supplementation with bioactive compounds had a positive impact which ranged from an increase in antioxidant capacity to a decrease in oxidative biomarkers such as malondialdehyde.
Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies
Monici Silva I et al. • European journal of oral sciences (2024)
Published by John Wiley & Sons Ltd.
- Only naringin, quercetin, proanthocyanidins, and glutaraldehyde showed statistically significant efficacy over untreated controls.
- In conclusion, proanthocyanidins positively affected both outcomes, suggesting they are prime candidates for translational research.
- Clinical studies are now essential to evaluate their real-world effectiveness against root caries.
Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review
Ranneh Y et al. • Nutrients (2024)
Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
- Most studies on silymarin showed a reduction in liver enzymes and lipid profile; however, no changes were observed in inflammatory cytokine levels.
- The dietary supplementation of hesperidin and naringenin or green tea extract caused improvements in liver enzyme, lipid profile, and inflammatory cytokine, while genistein supplementation did not modulate blood lipid profile.
- In conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD.
Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review
Ungureanu LB et al. • Medicina (Kaunas, Lithuania) (2023)
Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.
- Results: Out of 1756 articles, 25 articles were selected with data on tissue homogenate used for biochemical analysis of oxidative and antioxidative markers, along with routine hematoxylin eosin (HE) and immunohistochemical analysis used for histopathological and immunohistochemical diagnosis.
- Drugs (antineoplastic drugs, antibiotics, and analgesics), alcohol, heavy metals, and fluoride can cause oxidative stress, resulting in morphological changes in different tissues, including in salivary glands.
- Further research warranted to confirm findings
Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
Buzdağlı Y et al. • International journal of environmental health research (2023)
As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.
- Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies.
- For the meta-analysis, eighteen studies were chosen.
- Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels.
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials
Shams-Rad S et al. • British journal of clinical pharmacology (2020)
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
- Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
- Published in British journal of clinical pharmacology (2020)
- Further research warranted to confirm findings
The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials
Lorzadeh E et al. • Chemico-biological interactions (2019)
The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected.
- The meta-analysis revealed that hesperidin significantly reduces Vascular Cell Adhesion Molecule 1 (VCAM-1) levels [weighted mean difference (WMD) = -22.81 ng/L, P = 0.041, n = 3].
- The present study suggests that although hesperidin supplementation significantly improves VCAM-1 levels; however, other inflammatory markers might not be affected.
- Further high-quality systematic reviews exploring the effect of hesperidin particularly on VCAM-1, ICAM-1, E-selectin, and interleukin 6 are still needed to confirm these results.
Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis
Tamer F et al. • Thrombosis and haemostasis (2022)
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- We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
- Lastly, we provide guidance on which compounds are of interest for further platelet-related research.Thieme.
- All rights reserved.
Impact of hesperidin in 100% orange juice on chronic disease biomarkers: A narrative systematic review and gap analysis
Tadros FJ et al. • Critical reviews in food science and nutrition (2022)
Steps can be taken in future research to improve the consistency of clinical study designs, methodology and outcomes.
- This narrative systematic review aimed to determine appropriate recommendations toward the dose and frequency of hesperidin consumption from 100% orange juice and conduct a gap analysis.
- Results showed that overall effect sizes from the studies were considerably weak.
- Although higher frequencies, doses, and concentration of hesperidin in 100% orange juice had an impact on global cognitive function, cardiac, insulin, inflammatory, antioxidant/phenolic, and oxidative stress outcomes compared to lower frequencies, doses, and concentration of hesperidin.
Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease
Pompilio G et al. • Phlebology (2021)
Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD.
- Sulodexide was included only in a single NMA for the proportion of patients with complete ulcer healing and it showed to have the highest probability of being the best treatment (48%) compared with pentoxifylline (37%) and MPFF (16%).
- Sulodexide is at least as effective as pentoxifylline and more effective than MPFF in improving the rate of ulcer healing in patients with CVD.
- VADs are effective in improving venous symptoms and signs, as was also shown by sulodexide in the meta-analysis of observational studies.
Inflammatory Activities in Type 2 Diabetes Patients With Co-morbid Angiopathies and Exploring Beneficial Interventions: A Systematic Review
Nwadiugwu MC • Frontiers in public health (2020)
Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.Copyright © 2021 Nwadiugwu.
- Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events.
- Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome.
- Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities.
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
Gandhi GR et al. • Nutrients (2020)
Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
- All articles identified were analyzed, and data were extracted using a standardized form.
- These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications.
- Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.