Gotu Kola Research
13 peer-reviewed studies · Evidence score: 7/10
Evidence of Potential Natural Products for the Management of Hypertrophic Scars
Meetam T et al. • Journal of evidence-based integrative medicine (2024)
More robust and well-designed clinical trials with large-scale and prolonged follow-up durations are required to clarify the benefits and risks of these agents.
- We reviewed the literature based on data from in vitro, in vivo, and clinical trials.
- A total of 23 clinical trials were identified in this review; most clinical trials were ranked as having uncertain results (level of evidence 2b; n = 16).
- More robust and well-designed clinical trials with large-scale and prolonged follow-up durations are required to clarify the benefits and risks of these agents.
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
Kushwah S et al. • Current neuropharmacology (2023)
The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
- A rich knowledge base of traditional herbal plants (Turmeric, Gingko, Ashwagandha, Shankhpushpi, Giloy, Gotu kola, Garlic, Tulsi, Ginger, and Cinnamon) combined with modern science could suggest new functional leads for Alzheimer's drug discovery.
- In this article Ayurveda, the ancient Indian herbal medicine system based on multiple clinical and experimental, evidence have been reviewed for treating AD and improving brain functioning.
- This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment.
The Safety and Efficacy of Botanicals with Nootropic Effects
Roe AL et al. • Current neuropharmacology (2021)
Data gaps are highlighted for both efficacy and safety to bring attention to unmet needs and future research.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
- Overall, nearly one-quarter (23%) of adults currently take a supplement to maintain or improve brain health or delay and reverse dementia.
- However, other botanicals that affect stress, focus, attention, and sleep have also been procured by dietary supplement companies developing products for improving both, short and long-term brain health.
- Botanicals are discussed in terms of available clinical efficacy data and current safety profiles.
Neuroprotective Herbs for the Management of Alzheimer's Disease
Gregory J et al. • Biomolecules (2021)
It is hoped that these medicinal plants can be used in drug discovery programs for identifying safe and efficacious small molecules for AD.
- Methods-This article systematically reviews recent studies that have investigated the role of neuroprotective herbs and their bioactive compounds for dementia associated with Alzheimer's disease and pre-Alzheimer's disease.
- PubMed Central, Scopus, and Google Scholar databases of articles were collected, and abstracts were reviewed for relevance to the subject matter.
- Conclusions-Medicinal plants have great potential as part of an overall program in the prevention and treatment of cognitive decline associated with AD.
Effect of Centella asiatica on Cognition and Oxidative Stress in an Aβ-Induced Alzheimer Disease Model
Lokanathan Y et al. • International Journal of Molecular Sciences (2021)
Centella asiatica compounds demonstrate neuroprotective and cognition-enhancing properties through antioxidant mechanisms.
- Neuroprotective effects through reduction of oxidative stress biomarkers
- Improved memory and learning outcomes in controlled studies
- Asiaticoside identified as primary active component for cognitive benefits
Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits
Chandrika UG et al. • Advances in food and nutrition research (2015)
All rights reserved.
- However, detailed scientific approaches on clinical trials regarding health benefits and nutritional values of C. asiatica are limited, hindering the perception of its benefits, mechanisms, and toxicity in order to develop new drug prototypes.
- In vitro studies have shown that the method of processing C. asiatica has an impact on its nutritional values and health-related beneficial compounds.
- The composition of its compounds is influenced by different biotic and abiotic factors which need to be studied in detail to provide information to the public in order to maximize the usage of this valuable plant.© 2015 Elsevier Inc.
Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits
Reddy KK et al. • Journal of the American Academy of Dermatology (2013)
Selected CAM therapies have been reported to promote wound healing, reduce edema or purpura, and provide anti-inflammatory effects.
- Selected CAM therapies have been reported to promote wound healing, reduce edema or purpura, and provide anti-inflammatory effects.
- Because of high rates of CAM use, surgeons should familiarize themselves with common uses, potential benefits, and complications.
- Further study of effects in the dermatologic surgery setting may improve the patient-doctor relationship and enhance outcomes.
Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females
Escalante G et al. • Journal of cosmetic dermatology (2019)
A twice-daily topical application of Lipoxyderm™ for 28 days compared to a placebo combined with a walking program and a restricted caloric intake is more effective at reducing thigh circumference (1.2 vs 0.8 cm), thigh skinfold thickness (3.7 vs 2.0 mm), and thigh fat mass (100.0 g vs 57.3 g).
- A significant time x group interaction was found for thigh circumference (F1,6 = 18.2, P = 0.005), skinfold thickness (F1,6 = 14.6, P = 0.009), and fat mass (F1,6 = 37.1, P = 0.001).
- Published in Journal of cosmetic dermatology (2019)
- Further research warranted to confirm findings
[Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy]
Kaziulin AN et al. • Voprosy pitaniia (2006)
In group combined treatment was significant improvement of clinical signs, psychometric tests, electroencephalography and serum biochemistry than in group with standard therapy, on term of 2 to 5 weeks.
- In group combined treatment was significant improvement of clinical signs, psychometric tests, electroencephalography and serum biochemistry than in group with standard therapy, on term of 2 to 5 weeks.
- Formula includes extracts of plants: Bacopa monneria, Gingko biloba, Cat's Claw, Gotu Kola, Rosemary.
- Further research warranted to confirm findings
Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults
Carlson JJ et al. • Journal of the American Dietetic Association (2007)
These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults.
- Seventy-eight subjects (87%) completed both baseline and 4-month testing (n=36 in placebo group, n=42 in ginkgo biloba group).
- One of six cognitive tests indicated significant protocol differences at 4 months (P=0.03), favoring the placebo.
- These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults.
Gotu kola for anxiety
Bradwejn J et al. • Journal of Clinical Psychopharmacology (2000)
Gotu kola significantly reduced anxiety response to startle.
- Reduced acoustic startle response
- Anxiolytic effects confirmed
- Single-dose efficacy
Centella asiatica for wound healing
Widgerow AD et al. • Wound Repair and Regeneration (2000)
Centella asiatic extract improved wound healing outcomes.
- Enhanced collagen synthesis
- Improved wound tensile strength
- Clinical wound healing benefits
Evaluation of liposome-encapsulated Centella asiatica ethanolic extract for enhanced in vitro and in vivo wound healing
Chonsut P et al. • Frontiers in Medical Technology (2026)
These findings indicate that liposomal encapsulation enhances the bioactivity of C. asiatica extract during the inflammatory and proliferative phases of wound repair, supporting further development of LEC as a topical wound-healing formulation.
- Liposome-encapsulated Centella asiatica extract reduced TNF-α and IL-1β and enhanced dermal fibroblast viability and migration in vitro.
- Topical application accelerated wound contraction in a rat excision model, reaching 99.9% closure by Day 12.
- Histology showed enhanced re-epithelialization, increased collagen deposition, and reduced inflammatory cell infiltration.