CoQ10 Research
48 peer-reviewed studies · Evidence score: 9/10
Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis
Hu X et al. • PeerJ (2023)
Carnitine was relatively effective in reducing body mass, while chromium, Omega-3, and selenium were beneficial for improving glucose metabolism.
- The network meta-analysis showed that carnitine, inositol, and probiotics reduced body weight and body mass index (BMI) compared to placebo, and carnitine outperformed the other supplements (SUCRAs: 96.04%, 97.73%, respectively).
- Omega-3 lowered fasting blood glucose (FBG) (SUCRAs: 93.53%), and chromium reduced fasting insulin (FINS) (SUCRAs: 72.90%); both were superior to placebo in improving insulin resistance index (HOMA-IR), and chromium was more effective than Omega-3 (SUCRAs: 79.99%).
- Selenium was potent in raising the quantitative insulin sensitivity index (QUICKI) (SUCRAs: 87.92%).
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
Zhang T et al. • Reproductive sciences (Thousand Oaks, Calif.) (2023)
The Author(s), under exclusive licence to Society for Reproductive Investigation.
- Only one RCT reported adverse events, and they found that patients had no adverse effects or symptoms following supplementation.
- The Author(s), under exclusive licence to Society for Reproductive Investigation.
- Further research warranted to confirm findings
Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis
Shang Y et al. • Advances in nutrition (Bethesda, Md.) (2024)
All rights reserved.
- The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates.
- Appropriate antioxidant treatment should be offered at a low dose according to the patient's age and ovarian reserve.
- This study was registered at PROSPERO as CRD42022359529.Copyright © 2024 The Authors.
Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis
Lin G et al. • Annals of medicine (2024)
These findings suggested that CoQ10 pretreatment is an effective intervention in improving IVF/ICSI outcomes for women with DOR.
- These findings suggested that CoQ10 pretreatment is an effective intervention in improving IVF/ICSI outcomes for women with DOR.
- Still, this meta-analysis included relatively limited sample sizes with poor descriptions of their methodologies.
- Rigorously conducted trials are needed in the future.
Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials
Hou S et al. • Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
- This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
- Published in Molecular nutrition & food research (2023)
- Further research warranted to confirm findings
TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis
Zhu F et al. • Reproductive biology and endocrinology : RB&E (2023)
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
- Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
- CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
- DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
Coenzyme Q10 for heart failure
Al Saadi T et al. • The Cochrane database of systematic reviews (2021)
The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
- Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
- There was low-quality evidence of inconclusive results between the coenzyme Q10 and control groups for the risk of myocardial infarction (RR 1.62, 95% CI 0.27 to 9.59; 1 study, 420 participants), and stroke (RR 0.18, 95% CI 0.02 to 1.48; 1 study, 420 participants).
- Coenzyme Q10 probably reduces hospitalisation related to heart failure (RR 0.62, 95% CI 0.49 to 0.78; 2 studies, 1061 participants; NNTB 9.7; moderate-quality evidence).
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
Liu Z et al. • The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
- CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
- Published in The Journal of clinical endocrinology and metabolism (2022)
- Further research warranted to confirm findings
Antioxidants for female subfertility
Showell MG et al. • The Cochrane database of systematic reviews (2017)
In this review, there was very low-quality evidence to show that taking an antioxidant may provide benefit for subfertile women, but insufficient evidence to draw any conclusions about adverse events.
- This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
- Heterogeneity was moderately high.There was insufficient evidence to determine whether there was a difference between the groups in rates of miscarriage (OR 0.79, 95% CI 0.58 to 1.08, P = 0.14, 18 RCTs, 2834 women, I2 = 23%, very low quality evidence).
- This suggests that, among subfertile women with an expected miscarriage rate of 7%, use of antioxidants would be expected to result in a miscarriage rate of between 4% and 7%.
Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis
Zhang Y et al. • Human reproduction update (2020)
Furthermore, high-level RCT studies using uniform standards for POR need to be incorporated into future meta-analyses.
- Meta-analysis examining CoQ10 efficacy
- Published in Human reproduction update (2020)
- Further research warranted to confirm findings
Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Daei S et al. • High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension (2024)
CoQ10 supplementation has a positive effect on FMD in a dose-dependent manner.
- The sensitivity analysis showed that the effect size was robust in FMD and VCAM.
- In meta-regression, changes in FMD percent were associated with the dose of supplementation (slope: 0.01; 95% CI: 0.004 to 0.03; p = 0.006).
- CoQ10 supplementation has a positive effect on FMD in a dose-dependent manner.
Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials
Talandashti MK et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2025)
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
- In adults, compared with placebo, these supplements did not significantly affect other outcomes, and omega-3 supplementation did not yield a statistically significant reduction in any of these outcomes.
- The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
- Further clinical trials of high quality appear to be beneficial.
The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis
Michaelsen MP et al. • Nutrients (2025)
This study found no convincing evidence of an effect of any dietary supplements on male infertility.
- This study found no convincing evidence of an effect of any dietary supplements on male infertility.
- Larger and more well-conducted randomized controlled trials focusing on specific supplements and considering pregnancy outcomes are needed.
- Further research warranted to confirm findings
Nutrition and bipolar disorder: a systematic review
Gabriel FC et al. • Nutritional neuroscience (2023)
The 27 interventional studies mainly focused on fatty acids, micronutrients and N-acetylcysteine (NAC).
- Systematic review examining CoQ10 efficacy
- Published in Nutritional neuroscience (2023)
- Further research warranted to confirm findings
Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis
Sazali S et al. • BMJ open (2021)
CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.
- There is no statistically significant reduction in severity of migraine headache with CoQ10 supplementation.
- CoQ10 supplementation reduced the duration of headache attacks compared with the control group (MD: -0.19; 95% CI: -0.27 to -0.11; random effects; I2 statistic=0%; p<0.00001).
- CoQ10 usage reduced the frequency of migraine headache compared with the control group (MD: -1.52; 95% CI: -2.40 to -0.65; random effects; I2 statistic=0%; p<0.001).
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials
Qu H et al. • Journal of the American Heart Association (2018)
Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
- Publication bias was evaluated by a funnel plot, Egger regression test, and the Begg-Mazumdar correlation test.
- Twelve randomized controlled trials with a total of 575 patients were enrolled; of them, 294 patients were in the CoQ10 supplementation group and 281 were in the placebo group.
- Conclusions CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials
Xu J et al. • BMC cardiovascular disorders (2024)
According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and brain natriuretic peptide level and improves left ventricular ejection fraction and 6-min walk test result in those with heart failure without major adverse effects.
- Meta-analysis examining CoQ10 efficacy
- Published in BMC cardiovascular disorders (2024)
- Further research warranted to confirm findings
Variation of the clinical spectrum and genotype-phenotype associations in Coenzyme Q10 deficiency associated glomerulopathy
Drovandi S et al. • Kidney international (2022)
All rights reserved.
- Isolated kidney involvement at diagnosis occurred in 34% of COQ2, 10.8% of COQ6 and 70.7% of COQ8B variant individuals.
- Classic infantile multiorgan involvement comprised 22% of the COQ2 variant cohort while 47% of them developed neurological symptoms at median age 2.7 years.
- None of the patients with COQ8B variants, but 50% of patients with COQ2 and COQ6 variants progressed to kidney failure by age five.
The Effect of Coenzyme Q10 Supplementation on Metabolic Status of Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Moradi M et al. • Complementary Therapies in Medicine (2019)
CoQ10 supplementation significantly reduced fasting blood glucose, HbA1c, and triglycerides in type 2 diabetic patients.
- Significant reduction in fasting blood glucose and HbA1c levels
- Triglyceride levels significantly decreased with CoQ10 supplementation
- Doses of 100-200mg/day showed optimal metabolic benefits
Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials
Parohan M et al. • Nutritional neuroscience (2020)
Conclusion: Pooled analyses of available randomized clinical trials suggest that Coenzyme Q10 supplementation may reduce the frequency of migraine attacks per month without affecting the severity or duration of migraine attacks.
- A meta-analysis of eligible studies was performed using the fixed effects model or the random effects model to estimate pooled effect size.
- Coenzyme Q10 supplementation significantly reduced the frequency of migraine attacks (weighted mean difference: -1.87 attacks/month, 95% CI: -2.69 to -1.05, p < 0.001) without significant heterogeneity among the studies (I 2 = 36.6%, p = 0.192).
- Results: Four randomized clinical trials with 221 participants were included.