Ceramides Research
40 peer-reviewed studies · Evidence score: 9/10
The metabolic profile of waist to hip ratio-A multi-cohort study
Lind L et al. • PloS one (2023)
Two sphingomyelins were inversely linked to body fat distribution in both men and women without being associated with fat mass, while very-large and large HDL particles were inversely associated with both fat distribution and fat mass.
- Of the 193 LC-MS-metabolites being associated with WHRadjfatmass in EpiHealth (false discovery rate (FDR) <5%), 52 were replicated in a meta-analysis of PIVUS and POEM.
- Two sphingomyelins were inversely linked to body fat distribution in both men and women without being associated with fat mass, while very-large and large HDL particles were inversely associated with both fat distribution and fat mass.
- If these metabolites represent a link between an impaired fat distribution and cardiometabolic diseases remains to be established.
Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies
Morze J et al. • Diabetes care (2022)
Several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk.
- Several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk.
- Published in Diabetes care (2022)
- Further research warranted to confirm findings
CERT2 ceramide- and phospholipid-based risk score and major adverse cardiovascular events: A systematic review and meta-analysis
Papazoglou AS et al. • Journal of clinical lipidology (2022)
Published by Elsevier Inc.
- Pooled risk ratio (RR) of MACE among patients with CERT2=4-6 was equal to 1.35 (95% confidence intervals, CI: 1.11-1.64).
- Patients with CERT2=7-8 had an 81% increased risk of MACE (RR=1.81, CI: 1.40-2.34), while those with CERT2=9-12 had a 165% increased risk of MACE (RR=2.65, CI: 1.85-3.80).
- Subgroup analysis in patients with chronic coronary syndrome yielded an adjusted hazard ratio for MACE equal to 1.20 (CI: 1.09-1.32) per one standard deviation increase of CERT2 score.
Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study
Jensen PN et al. • Cardiovascular diabetology (2022)
While replication of the findings from the SHS in other populations is warranted, our findings add to a growing body of research suggesting that ceramides, in particular Cer-16, not only are associated with higher diabetes risk, but may also be associated with higher CVD risk after diabetes onset.
- While replication of the findings from the SHS in other populations is warranted, our findings add to a growing body of research suggesting that ceramides, in particular Cer-16, not only are associated with higher diabetes risk, but may also be associated with higher CVD risk after diabetes onset.
- We also find support for the hypothesis that sphingomyelins with a very long chain saturated fatty acid are associated with lower CVD risk among adults with type 2 diabetes.
- Further research warranted to confirm findings
Ceramides and risk of major adverse cardiovascular events: A meta-analysis of longitudinal studies
Mantovani A et al. • Journal of clinical lipidology (2020)
Higher plasma levels of Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1) were associated with major adverse cardiovascular events, whereas plasma levels of Cer(d18:1/22:0) and Cer(d18:1/24:0) were not.
- Conversely, no association with plasma levels of Cer(d18:1/22:0) (HR 1.14 95% CI 0.88-1.47, I2 = 88%) and Cer(d18:1/24:0) (HR 0.97, 95% CI 0.89-1.05, I2 = 73%) was found.
- Higher plasma levels of Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1) were associated with major adverse cardiovascular events, whereas plasma levels of Cer(d18:1/22:0) and Cer(d18:1/24:0) were not.
- Additional research is required to elucidate the different role of ceramides on pathways involved in cardiovascular disease.
Effect of oral intake of phytoceramides on skin hydration: A systematic review and meta-analysis of clinical studies
Tessema EN et al. • Journal of Cosmetic Dermatology (2021)
Oral phytoceramide supplementation significantly improved skin hydration and reduced transepidermal water loss in clinical studies.
- Oral phytoceramides significantly increased skin hydration measured by corneometry
- Transepidermal water loss (TEWL) was significantly reduced after 4-12 weeks
- Both wheat-derived and rice-derived phytoceramides showed efficacy
Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder
Modesti MN et al. • Lipids in health and disease (2025)
OCD was associated with sphingolipid signaling and peroxisomal metabolism.
- Systematic review examining Ceramides efficacy
- Published in Lipids in health and disease (2025)
- Further research warranted to confirm findings
The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis-A Systematic Review of Recent Literature
Klekowski J et al. • International journal of molecular sciences (2024)
Although numerous lipid species have been suggested as potential diagnostic markers, the establishment of standardized methods and the conduct of large-scale studies are necessary to facilitate their clinical application.
- In tissues, lysophospholipids, ceramides, and TAGs were among the most altered lipids, while unsaturated fatty acids also emerged as potential biomarkers.
- In-depth analysis requires both cell culture and animal studies.
- CRC involves multiple lipid metabolism alterations.
Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review
Upadhyay PR et al. • Cells (2023)
Considering the broad cytokine dysregulation observed in AD pathophysiology, understanding the role of each of these in lipid abnormalities and barrier dysfunction will help in developing therapeutics to best achieve barrier homeostasis in AD patients.
- To better define the role of cytokines in stratum corneum lipid abnormalities related to AD, we conducted a systematic review of biomedical literature in PubMed from its inception to 5 September 2023.
- Consistent with the dominant TH2 skewness seen in AD, type 2 cytokines were featured prominently as possessing a central role in epidermal lipid alterations in AD skin.
- The cytokines associated with TH1 and TH17 were also identified to affect barrier lipids.
Similar Alterations of the Stratum Corneum Ceramide Profile in Atopic Dermatitis, Psoriasis, and Ichthyosis: Results from a Systematic Review and Meta-Analysis
Rousel J et al. • The Journal of investigative dermatology (2024)
This meta-analysis examined the effects of Ceramides.
- Meta-analysis examining Ceramides efficacy
- Published in The Journal of investigative dermatology (2024)
- Further research warranted to confirm findings
Attenuation of Atopic Dermatitis in Newborns, Infants, and Children With Prescription Treatment and Ceramide-Containing Skin Care: A Systematic Literature Review and Consensus
Schachner LA et al. • Journal of drugs in dermatology : JDD (2024)
Using gentle cleansers and moisturizers containing barrier lipids from birth onward may delay AD occurrence and mitigate severity in predisposed infants.J Drugs Dermatol. 2024;23(3): doi:10.36849/JDD.7894.
- Systematic review examining Ceramides efficacy
- Published in Journal of drugs in dermatology : JDD (2024)
- Further research warranted to confirm findings
The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review
Carrard J et al. • Sports medicine (Auckland, N.Z.) (2022)
Cardiorespiratory fitness was associated with circulating and muscle lipidome composition.
- Cardiorespiratory fitness was associated with circulating and muscle lipidome composition.
- Causality of the revealed associations at the molecular species level remains to be investigated further.
- Finally, included studies were heterogeneous in terms of participants' characteristics and analytical and statistical approaches.
Molecular characterization of xerosis cutis: A systematic review
Amin R et al. • PloS one (2021)
An unexpectedly high number of various molecules to quantify xerosis cutis was found.
- An unexpectedly high number of various molecules to quantify xerosis cutis was found.
- There is substantial heterogeneity regarding molecular marker selection, tissue sampling and laboratory analyses.
- Empirical evidence is also heterogeneous regarding possible associations with dry skin.
The Importance of Skincare for Neonates and Infants: An Algorithm
Schachner L et al. • Journal of drugs in dermatology : JDD (2021)
The current algorithm focuses on neonatal and infant healthy skin that can benefit from skincare.
- The current algorithm focuses on neonatal and infant healthy skin that can benefit from skincare.
- When applied from birth onwards, gentle cleansers and moisturizers containing barrier lipids help maintain the protective skin barrier.
- J Drugs Dermatol. 2021;20(11):1195-1205. doi:10.36849/JDD.6219.
Associations of depression status with plasma levels of candidate lipid and amino acid metabolites: a meta-analysis of individual data from three independent samples of US postmenopausal women
Huang T et al. • Molecular psychiatry (2021)
The Author(s), under exclusive licence to Springer Nature Limited.
- Prevalence rates of positive depression status were 24.4% (WHI-OS), 25.7% (WHI-HT), and 44.7% (NHSII-MBS).
- After multivariable adjustment, positive depression status was associated with higher levels of glutamate and PC 36 : 1/38 : 3, and lower levels of tryptophan and GABA-to-glutamate and GABA-to-glutamine ratio (FDR-p < 0.05).
- Positive associations with LPE 18 : 0/18 : 1 and inverse associations with valine and serotonin were also observed, although these associations did not survive FDR adjustment.
Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo
Collins LZ et al. • International journal of cosmetic science (2018)
Males show a greater response than females to 1% ZnPT shampoo, while females show a greater response than males to non-AD shampoo.
- Response to 1% ZnPT vs. non-AD shampoo was greater in males than in females at all time points; after 4 weeks, the between-treatment difference in TWHS-AF was -17.5 (95% confidence interval [CI] -19.5, -15.5) in males and -11.1 (-13.2, -8.9) in females.
- Sex-related differences were observed between males and females in response to both 1% ZnPT and non-AD shampoos.
- Males had a stronger response than females to treatment with 1% ZnPT shampoo, while dandruff decreased to a greater extent in females than in males when using non-AD shampoo.
Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
Peterson LR et al. • Journal of the American Heart Association (2018)
The ratio of C24:0/C16:0 ceramides in blood may be a valuable new biomarker of CHD risk, HF risk, and all-cause mortality in the community.
- Moreover, the C24:0/C16:0 and C22:0/C16:0 ceramide ratios were inversely associated with all-cause mortality (C24:0/C16:0: hazard ratio, 0.60; 95% confidence interval, 0.56-0.65; P<0.0001; C22:0/C16:0: hazard ratio, 0.65; 95% confidence interval, 0.60-0.70; P<0.0001).
- The ratio of C24:0/C16:0 ceramides in blood may be a valuable new biomarker of CHD risk, HF risk, and all-cause mortality in the community.
- Further research warranted to confirm findings
Ceramides and depression: A systematic review
Dinoff A et al. • Journal of affective disorders (2017)
Pharmacotherapy targeting ceramide metabolism may be a novel treatment option for depression.
- Pharmacotherapy targeting ceramide metabolism may be a novel treatment option for depression.
- A number of pharmacological targets exists for ceramide reduction and a number of currently approved medications inhibit ceramide production.
- More evidence, pre-clinical and clinical, is warranted to determine the extent and consistency of the role of ceramides in depression.
Insulin Resistance and Blood Pressure Control on Cognitive Outcomes
Fan C et al. • Hypertension (Dallas, Tex. : 1979) (2026)
In patients with hypertension with TyG >9.07, lowering blood pressure to <120 mm Hg reduced dementia incidence more than standard control, hinting TyG modifies treatment effects, possibly via glycosyl ceramide.
- Our mediation analysis identified a potential pathway linking the TyG index to dementia via plasma glycosyl ceramide levels, accounting for ≈10.8% of the total effect.
- In patients with hypertension with TyG >9.07, lowering blood pressure to <120 mm Hg reduced dementia incidence more than standard control, hinting TyG modifies treatment effects, possibly via glycosyl ceramide.
- Further research warranted to confirm findings
Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
Tempark T et al. • Journal of cosmetic dermatology (2024)
Ceramide and niacinamide-containing moisturizer in combination with anti-acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris.
- CCM could significantly improve the non-inflammatory, inflammatory, and total acne lesions compared with hydrophilic cream after week 8 of treatment.
- Interestingly, there was an improvement of global worst score, hemoglobin index, melanin index, TEWL, skin hydration, sebum production, and skin surface pH, with no statistically significant differences between the two treatments.
- Ceramide and niacinamide-containing moisturizer in combination with anti-acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris.