Astaxanthin Research
40 peer-reviewed studies · Evidence score: 7.5/10
The effect of progesterone supplementation for luteal phase support in natural cycle frozen embryo transfer: a systematic review and meta-analysis based on randomized controlled trials
Jiang Y et al. • Fertility and sterility (2023)
Overall, moderate-quality evidence suggested that progesterone supplementation for LPS was associated with increased LBR and CPR in NC-FET cycles.
- The results of the meta-analysis showed that progesterone supplementation was associated with increased LBR (RR, 1.42; 95% CI, 1.15-1.75; I2 = 0%, moderate-quality evidence) and CPR (RR, 1.30, 95% CI, 1.07-1.57; I2 = 0%, moderate-quality evidence) in patients undergoing NC-FET cycles.
- Progesterone supplementation was associated with a higher LBR and CPR in tNC-FET cycles.
- However, the effectiveness of progesterone supplementation in mNC-FET cycles should be further verified by larger RCTs.
How long does tendinopathy last if left untreated? Natural history of the main tendinopathies affecting the upper and lower limb: A systematic review and meta-analysis of randomized controlled trials
Garzón M et al. • Musculoskeletal science & practice (2024)
This review provides limited conclusions about natural history of tendinopathies.
- Pooled results demonstrated significant pain (SMD = 0.30, 95%CI: 0.19-0.41) and physical function improvement (SMD = 0.38, 95%CI: 0.28-0.48).
- This review provides limited conclusions about natural history of tendinopathies.
- Future studies should incorporate true no-intervention groups to accurately reflect tendinopathy's natural progression.
Efficacy and safety of natural killer cell therapy in patients with solid tumors: a systematic review and meta-analysis
Park H et al. • Frontiers in immunology (2024)
Safety profiles were favorable, with fatigue being the most common adverse event.
- NK cell therapies demonstrated promising ORRs, particularly 72.3% in hepatocellular carcinoma, often in combination with local therapies.
- Published in Frontiers in immunology (2024)
- Further research warranted to confirm findings
Effects of GLP1RAs on pregnancy rate and menstrual cyclicity in women with polycystic ovary syndrome: a meta-analysis and systematic review
Zhou L et al. • BMC endocrine disorders (2023)
Prescription of GLP1RAs improves natural pregnancy rate, menstrual cyclicity and insulin sensitivity, anthropometrics, hormonal indexes in PCOS women.
- GLP1RAs usage was associated with an improvement in natural pregnancy rate (RR: 1.72, 95% CI 1.22 to 2.43, P = 0.002, I2 = 0%) and menstrual regularity (SMD: 1.72, 95% CI 0.60 to 2.85, P < 0.001, I2 = 95.6%).
- There were no statistically significant differences in total pregnancy rate, IVF pregnancy rate between two groups, but total PR elevated in a short time after GLP1RAs as shown in subgroup analysis.
- Prescription of GLP1RAs improves natural pregnancy rate, menstrual cyclicity and insulin sensitivity, anthropometrics, hormonal indexes in PCOS women.
Dietary factors and onset of natural menopause: A systematic review and meta-analysis
Grisotto G et al. • Maturitas (2022)
Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial.
- Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial.
- Prospero id: CRD42021232087.
- Further research warranted to confirm findings
Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and meta-analysis
Von Woon E et al. • Human reproduction update (2022)
Measurement of uNK level/activity may be more useful as a diagnostic tool, however, a standardized reference range must be established before this can be of clinical use.
- Meta-analysis examining Astaxanthin efficacy
- Published in Human reproduction update (2022)
- Further research warranted to confirm findings
Prevalence, Trajectory, and Factors Associated With Patient-Reported Nonmotor Outcomes After Stroke: A Systematic Review and Meta-Analysis
Ozkan H et al. • JAMA network open (2025)
Patient-reported nonmotor outcomes were common after stroke.
- Meta-regression analysis showed no significant improvement over time for most nonmotor outcomes, except pain (coefficient = -11.0%; P = .05) and sexual dysfunction (coefficient = -24.1%; P < .001).
- The heterogeneity ranged between 52% and 98% across all studies.
- Patient-reported nonmotor outcomes were common after stroke.
Cycle regimens for endometrial preparation prior to frozen embryo transfer
Ghobara T et al. • The Cochrane database of systematic reviews (2025)
As the evidence was often of low certainty, and the confidence intervals were wide and therefore consistent with possible benefit and harm, we are uncertain whether one cycle regimen is more effective and safer than another in preparation for FET in subfertile women.
- We are uncertain of a difference in miscarriage rate (OR 0.09, 95% CI 0.00 to 1.61; 1 study, 241 participants; low-certainty evidence) and ongoing pregnancy rate (OR 1.01, 95% CI 0.59 to 1.74; 1 study, 241 participants; low-certainty evidence).
- There is probably little or no difference in ongoing pregnancy rate (OR 1.29, 95% CI 0.90 to 1.85; 3 studies, 653 participants; moderate-certainty evidence) or in miscarriage rate (OR 0.83, 95% CI 0.43 to 1.61; 4 studies, 798 participants; moderate-certainty evidence).
- We are uncertain whether the use of HT FET decreases miscarriage rate compared to modified natural cycle FET (OR 0.51, 95% CI 0.14 to 1.87; 2 studies, 317 participants; very low-certainty evidence).
Lurasidone versus typical antipsychotics for schizophrenia
Storman D et al. • The Cochrane database of systematic reviews (2025)
We are very uncertain about whether lurasidone offers benefits to the mental state, total serious adverse events, or severe adverse events when compared to typical antipsychotics for people with schizophrenia.
- We are very uncertain about whether lurasidone offers benefits to the mental state, total serious adverse events, or severe adverse events when compared to typical antipsychotics for people with schizophrenia.
- The evidence included in this review is of very low certainty, derived from two small trials.
- Study limitations (risk of bias) and imprecise results impacted our confidence in the evidence.
Prevalence and clinical outcomes of transthyretin amyloidosis: a systematic review and meta-analysis
Antonopoulos AS et al. • European journal of heart failure (2022)
We report the prevalence of ATTR in various population subgroups and provide survival estimates for the natural course of disease and the effects of novel therapeutics.
- ATTR 2-year survival was higher on tafamidis/patisiran compared to natural disease course (79.9%, 95% CI 74.4-85.3 vs. 72.4%, 95% CI 69.8-74.9, p < 0.05).
- We report the prevalence of ATTR in various population subgroups and provide survival estimates for the natural course of disease and the effects of novel therapeutics.
- Important gaps in worldwide epidemiology research in ATTR were identified.
Impact of Radiographic Bronchiectasis in COPD
Shi L et al. • Respiratory care (2020)
This meta-analysis confirmed the significant associations of the presence of bronchiectasis with the natural history, disease course, and outcomes in COPD.
- A total of 415,257 subjects with COPD from 18 observational studies were eligible; bronchiectasis was present in 25,929 subjects (6.24%).
- This meta-analysis confirmed the significant associations of the presence of bronchiectasis with the natural history, disease course, and outcomes in COPD.
- The COPD-bronchiectasis phenotype had adverse effects on subjects' health condition and prognosis.
Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin (DES)-Associated Cardiomyopathy
Asatryan B et al. • Circulation. Genomic and precision medicine (2025)
DES cardiomyopathy exhibits heterogeneous phenotypes and a distinct natural history, characterized by high familial penetrance and a substantial MACE burden.
- A total of 230 patients were included (52.6% men, 52.2% probands, median age: 31 years [22.0-42.8] at first evaluation, median follow-up: 3 years [0-11.0]).
- Overall, 132 (57.4%) patients developed MACE, with 96 (41.7%) having cardiac conduction disease, 36 (15.7%) sustained VA, and 43 (18.7%) HF events.
- Familial penetrance of cardiac disease was 63.6% among relatives with pathogenic/LP DES variants.
The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis
Sossen B et al. • The Lancet. Respiratory medicine (2023)
All rights reserved.
- Reversion from microbiologically positive to undetectable disease in prospective cohorts occurred at an annualised rate of 12% (6·8-18·0).
- All rights reserved.
- Further research warranted to confirm findings
Prevalence and natural history of depression after stroke: A systematic review and meta-analysis of observational studies
Liu L et al. • PLoS medicine (2023)
In this study, we observed that stroke survivors with early-onset depression (within 3 months after stroke) are at high risks for remaining depressed and make up two-thirds of the incident cases during 1 year after stroke.
- In this study, we observed that stroke survivors with early-onset depression (within 3 months after stroke) are at high risks for remaining depressed and make up two-thirds of the incident cases during 1 year after stroke.
- This highlights the need for ongoing clinical monitoring of patients depressed shortly after stroke.
- Further research warranted to confirm findings
Psyllium is a natural nonfermented gel-forming fiber that is effective for weight loss: A comprehensive review and meta-analysis
Gibb RD et al. • Journal of the American Association of Nurse Practitioners (2023)
Six studies meeting inclusion criteria were identified (total n = 354).
- Six studies meeting inclusion criteria were identified (total n = 354).
- Published in Journal of the American Association of Nurse Practitioners (2023)
- Further research warranted to confirm findings
Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials
Ma B et al. • Nutrition research (New York, N.Y.) (2022)
All rights reserved.
- Compared with placebo, astaxanthin significantly reduced blood malondialdehyde concentration (standardized mean difference [SMD]: -0.95; 95% CI, -1.67 to -0.23; P = .01).
- The lowering effect of astaxanthin supplementation on malondialdehyde was particularly significant in type 2 diabetes mellitus (T2DM) patients (SMD: -0.64; 95% CI, -1.26 to -0.01; P < .05).
- Astaxanthin significantly reduced blood interleukin-6 concentration in T2DM patients (weighted mean difference: -0.70 pg/mL; 95% CI, -1.29 to -0.11 pg/mL; P = .02).
Machine Learning and Natural Language Processing in Mental Health: Systematic Review
Le Glaz A et al. • Journal of medical Internet research (2021)
Machine learning and NLP models have been highly topical issues in medicine in recent years and may be considered a new paradigm in medical research.
- A total of 327 articles were identified, of which 269 (82.3%) were excluded and 58 (17.7%) were included in the review.
- Machine learning and NLP models have been highly topical issues in medicine in recent years and may be considered a new paradigm in medical research.
- However, these processes tend to confirm clinical hypotheses rather than developing entirely new information, and only one major category of the population (ie, social media users) is an imprecise cohort.
Assessment of the Frequency of Dual Allergy to Penicillins and Cefazolin: A Systematic Review and Meta-analysis
Sousa-Pinto B et al. • JAMA surgery (2021)
These findings suggest that most patients with a penicillin allergy history may safely receive cefazolin.
- Cefazolin allergy was identified in 44 participants with a history of penicillin allergy, resulting in a dual allergy meta-analytical frequency of 0.7% (95% credible interval [CrI], 0.1%-1.7%; I2 = 74.9%).
- Such frequency was lower for participants with unconfirmed (0.6%; 95% CrI, 0.1%-1.3%; I2 = 54.3%) than for those with confirmed penicillin allergy (3.0%; 95% CrI, 0.01%-17.0%; I2 = 88.2%).
- Thirteen studies exclusively assessed surgical patients (n = 3884), among whom 0.7% (95% CrI, 0%-3.3%; I2 = 85.5%) had confirmed allergy to cefazolin.
Effect of astaxanthin supplementation on female fertility and reproductive outcomes: a systematic review and meta-analysis of clinical and animal studies
Maleki-Hajiagha A et al. • Journal of ovarian research (2024)
This systematic review shows that AST supplementation may improve assisted reproductive technology outcomes by enhancing oocyte quality and reducing OS in the reproductive organs.
- This systematic review shows that AST supplementation may improve assisted reproductive technology outcomes by enhancing oocyte quality and reducing OS in the reproductive organs.
- However, the evidence is limited by the heterogeneity, risk of bias, and small sample size of the included studies.
- Further research warranted to confirm findings
Astaxanthin for skin health: A systematic review
Davinelli S et al. • Marine Drugs (2018)
Astaxanthin supplementation improved skin elasticity, moisture, and reduced wrinkles.
- Improved skin elasticity
- Increased moisture retention
- Reduced wrinkle depth