Apigenin Research
39 peer-reviewed studies · Evidence score: 8/10
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Liang H et al. • Renal failure (2025)
Through rigorous experimental validation, our study demonstrates AS's significant clinical efficacy in managing DN.
- Meanwhile, when the treatment duration exceeds 12 weeks, AS demonstrated a significant reduction in fasting blood glucose levels, indicating a time-dependent effect.
- Through rigorous experimental validation, our study demonstrates AS's significant clinical efficacy in managing DN.
- Specifically, AS has been shown to enhance renal function, ameliorate renal fibrosis, and positively influence iron metabolism.
Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?
Olasehinde TA et al. • Inflammopharmacology (2024)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
- Overall, apigenin inhibited neuroinflammation which suggests it confers neuroprotective effect against neuronal degeneration in some neurodegenerative conditions.
- This review provides important neuropharmacological information on the neuroprotective mechanisms of apigenin against neuroinflammation which may be useful for future preclinical and clinical studies.© 2024.
- The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives
Aktaş E et al. • CNS neuroscience & therapeutics (2025)
Although levodopa is indispensable for the symptomatic management of PD, emerging evidence supports the integration of plant-derived bioactive compounds as adjunct therapies with disease-modifying potential.
- Although levodopa is indispensable for the symptomatic management of PD, emerging evidence supports the integration of plant-derived bioactive compounds as adjunct therapies with disease-modifying potential.
- Future research should prioritize improving bioavailability, developing standardized formulations, and conducting long-term clinical trials to evaluate the translational applicability of these natural agents in Parkinson's disease therapy.
- Further research warranted to confirm findings
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus
Faysal M et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
- The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
- This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.© 2025.
A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders
Gote S et al. • Inflammopharmacology (2025)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
- The utilization of natural products holds significant promise for the prevention and treatment of neurodegenerative diseases (ND).
- The review provides evidence that natural products and their bioactive compounds could be beneficial in the treatment of neurodegenerative disorders.
- This article delineates the Keap1-Nrf2-ARE pathway's role in ND progression, shedding light on the therapeutic efficacy of natural products and their bioactive constituents that have demonstrated neuroprotective properties.© 2025.
Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements
Zhang N et al. • Current neuropharmacology (2025)
The results show some efficacy of apigenin in the treatment of AD models.
- The results show some efficacy of apigenin in the treatment of AD models.
- However, further clinical studies are needed to confirm the clinical efficacy of apigenin.
- Further research warranted to confirm findings
Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug
Shao G et al. • Journal of ethnopharmacology (2024)
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
- However, clinical data describing the mode of action of the naturally active compounds of POL are still lacking.
- In addition, pharmacokinetic data for POL compounds, such as changes in drug dose and absorption rates, cannot be extrapolated from animal models and need to be measured in patients in clinical trials.
Potential therapeutic effects of apigenin for colorectal adenocarcinoma: A systematic review and meta-analysis
Ahmadzadeh K et al. • Cancer medicine (2024)
Our results demonstrated that apigenin, through reducing cell viability, inducing growth inhibition, apoptosis, and cell cycle arrest, and also by decreasing the tumor size, can be considered as a possible adjuvant agent in the management of colorectal adenocarcinoma.
- Our results demonstrated that apigenin, through reducing cell viability, inducing growth inhibition, apoptosis, and cell cycle arrest, and also by decreasing the tumor size, can be considered as a possible adjuvant agent in the management of colorectal adenocarcinoma.
- However, further in vivo studies are needed before any efforts to translate the current evidence into clinical studies.
- Further research warranted to confirm findings
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models
Singh D et al. • Critical reviews in oncology/hematology (2022)
Our analysis suggests that Apigenin has potential anticancer effects against various cancers.
- Further, it has no significant effect on the animal's body-weight (SMD=-0.345, 95% CI: -0.832 to 0.143, p = 0.165).
- Our analysis suggests that Apigenin has potential anticancer effects against various cancers.
- However, the poor symmetry of the funnel plot suggested publication bias.
The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review and meta-analysis of preclinical evidence
Rahimi A et al. • Inflammopharmacology (2022)
Overall, our findings showed the immunomodulatory potential of apigenin as an alternative treatment for the suppression of inflammatory responses and OS in different types of lung injury diseases.
- Overall, our findings showed the immunomodulatory potential of apigenin as an alternative treatment for the suppression of inflammatory responses and OS in different types of lung injury diseases.
- Nevertheless, due to the paucity of clinical studies, reliable preclinical models, and clinical settings, evaluating the influence of apigenin on lung injury is required in the future.
- Before conducting large-scale clinical trials, detailed human pharmacokinetic studies are also needed to establish dosage ranges and determine the initial safety and tolerability of apigenin.
Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis
Tamer F et al. • Thrombosis and haemostasis (2022)
All rights reserved.
- We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance.
- Lastly, we provide guidance on which compounds are of interest for further platelet-related research.Thieme.
- All rights reserved.
The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review
Cao Y et al. • Pharmacological research (2021)
Published by Elsevier Ltd.
- So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
- It is believed that more breakthrough studies are needed.
- Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.Copyright © 2021.
A review of the ethnopharmacology, phytochemistry, pharmacology, and quality control of Scutellaria barbata D. Don
Wang L et al. • Journal of ethnopharmacology (2020)
The heat-clearing effects of S. barbata could be attributed to its anti-inflammatory and hepatoprotective activities, whereas its detoxifying effects might be due to the anti-microbial functions of neo-clerodane diterpenoids and flavones.
- The heat-clearing effects of S. barbata could be attributed to its anti-inflammatory and hepatoprotective activities, whereas its detoxifying effects might be due to the anti-microbial functions of neo-clerodane diterpenoids and flavones.
- S. barbata may display anti-tumor effects and through active ingredient analysis, neo-clerodane diterpenoids are suggested to be its representative compounds.
- Overall, many pre-clinical studies have been conducted but very little concrete evidences are available on its specific effects, which are of therapeutic relevance.
Clinical practice guideline on treating influenza in adult patients with Chinese patent medicines
Wu L et al. • Pharmacological research (2020)
All rights reserved.
- The strength of all recommendations was weak.
- Traditional Chinese medicine has great potential to help in the fight against influenza worldwide, but more high-quality studies are still needed to strengthen the evidence.Copyright © 2020 The Author(s).
- Published by Elsevier Ltd..
Prevention from radiation damage by natural products
Fischer N et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2018)
Some secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation.
- Some secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation.
- These results warrant further analysis to develop phytochemicals as radioprotectors for clinical use.
- Further research warranted to confirm findings
Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis
Sanadgol N et al. • Current drug targets (2017)
Further studies with a focus on the molecular mechanisms of the protective natural compounds are needed to decrease possible side effects and to develop new medicines for MS.
- Further studies with a focus on the molecular mechanisms of the protective natural compounds are needed to decrease possible side effects and to develop new medicines for MS.
- Apigenin, chrysin, baicalein, cyanidin, flavone glycoside, daidzein, coumestrol, sulforaphane, bee venom and huperzine A are the candidates for more prospective investigations.
- Further research warranted to confirm findings
Interventions to improve chronic cyclosporine A nephrotoxicity through inhibiting renal cell apoptosis: a systematic review
Xiao Z et al. • Chinese medical journal (2013)
There are three group interventions for CCN.
- These interventions significantly improved the CCN, renal cell apoptosis and renal dysfunction through intervening in four apoptotic pathways in animals or protected renal cells from apoptosis induced by CsA and increased cell survival through respectively four pathways in vitro.
- There are three group interventions for CCN.
- Especially anti-oxidant drugs can significantly improve CCN, renal cell apoptosis and renal dysfunction.
Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
Chang H et al. • Nutrients (2018)
Conclusions: The present study suggested that high intake of flavonols (such as quercetin) may reduce the risk of colon cancer, and high intake of flavones (such as apigenin) may reduce the risk of rectal cancer.
- High intake of dietary flavonols, flavones and anthocyanidins may decrease the risk of colorectal cancer; the pooled odds ratio (OR) for the highest intake compared with the lowest was 0.70 (0.54⁻0.90), 0.79 (0.83⁻0.99) and 0.78 (0.64⁻0.95), respectively.
- No association between the intake of total flavonoids, flavanones or flavan-3-ols and the risk of colorectal cancer was observed.
- Conclusions: The present study suggested that high intake of flavonols (such as quercetin) may reduce the risk of colon cancer, and high intake of flavones (such as apigenin) may reduce the risk of rectal cancer.
The effect of celery (Apium graveolens L.) on fertility: A systematic review
Kooti W et al. • Journal of complementary & integrative medicine (2017)
Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.
- Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant.
- Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis.
- In this regard, the doses used and the treatment time while using the plant must be accurately investigated.
Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study
Zargaran A et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2018)
Results supported the efficacy of chamomile oleogel as a pain relief in migraine without aura.
- There was 4.48 ± 0.01 μl/ml of chamazulene and 0.233 mg/g of apigenin in the preparation (by correcting the amount with extraction ratio).
- Thirty-eight patients in the drug-placebo and 34 patients in the placebo-drug groups (a total number of 72 patients as per protocol) completed the process in the randomized controlled trial (RCT).
- Adapted results from the questionnaires showed that pain, nausea, vomiting, photophobia, and phonophobia significantly (p < 0.001) decreased by using chamomile oleogel on the patients after 30 min.