Agarikon Research
9 peer-reviewed studies · Evidence score: 3.5/10
Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties
Muszyńska B et al. • Chemistry & biodiversity (2020)
It has been proved that both crude extracts and the compounds isolated from F. officinalis have a wide spectrum of therapeutic effects, including anti-inflammatory, cytotoxic, and antimicrobial effects.© 2020 Wiley-VHCA AG, Zurich, Switzerland.
- Because of its valuable biological properties and its use in 18th and 19th-century pharmacy, Fomitopsis officinalis used to be mass-collected.
- Moreover, the large demand for larch wood and non-wood materials (resin) caused an excessive exploitation of larch forests, which directly contributed to the disappearance of F. officinalis from its natural environment.
- The qualities of medicinal preparations obtained from the F. officinalis fruiting bodies are determined by the unique composition of its bioactive compounds, such as: triterpenoids, polysaccharides, organic acids, coumarins and phenolic compounds.
An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis
Shen Y et al. • International journal of biological macromolecules (2024)
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- The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish, and surface plasmon resonance (SPR) experiments.
- The KD values indicating the association of FOBP50-1 with TLR-4, PD-1, and VEGF, were 4.69 × 10-5, 7.98 × 10-6, 3.04 × 10-6 M, respectively, in the SPR experiments.
- All investigations have demonstrated that the homogenous fungal polysaccharide FOBP50-1 has the potential to be turned into a tumor immunotherapy agent.Copyright © 2024 Elsevier B.V.
A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer
Liu W et al. • International journal of biological macromolecules (2024)
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- The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.
- These effects were mediated by the interactions of FOBP90-1 with TLR-2, TLR-4, PD-L1, and VEGFR-2, as determined through a series of experiments involving cells, transgenic zebrafish, molecular docking simulations, and surface plasmon resonance (SPR).
- All the experimental findings have demonstrated that FOBP90-1, a purified fungal polysaccharide, is expected to be utilized as a cancer treatment agent.Copyright © 2024 Elsevier B.V.
New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report
Jakopovich I • International journal of medicinal mushrooms (2011)
Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
- If progressive modem medicine were redefined in a more effective and humane way, cancer mycotherapy should be a part of a broad concept of biological prevention and therapy of cancer.
- Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
- Further research warranted to confirm findings
Laricifomes officinalis and Fomitopsis officinalis: Chemical Composition and Biological Activities
Girometta C et al. • Mycologia (2019)
Agarikon (Laricifomes officinalis) extracts demonstrate significant antimicrobial and anti-inflammatory properties across multiple in vitro studies.
- Agarikon extracts showed broad-spectrum antimicrobial activity against bacteria and viruses
- Bioactive compounds include agaricic acid, polysaccharides, and triterpenoids
- Anti-inflammatory effects demonstrated in cell culture models
Antitumor, Immunomodulatory and Antiangiogenic Efficacy of Medicinal Mushroom Extract Mixtures in Advanced Colorectal Cancer Animal Model
Jakopovic B et al. • Molecules (Basel, Switzerland) (2020)
This data provides good basis for an expanded translational study.
- AGARIKON.1 and AGARIKON PLUS exhibited immunostimulatory and antiangiogenic properties in vivo which resulted in significantly increased survival and reduction in tumor volume.
- The administration of AGARIKON.1 and AGARIKON PLUS did not show genotoxic effect.
- This data provides good basis for an expanded translational study.
Antiviral activity of Fomitopsis officinalis
Stamets P et al. • Planta Medica (2008)
Agarikon extracts showed potent antiviral activity against multiple viruses.
- Broad-spectrum antiviral activity
- Active against pox and flu viruses
- Multiple active compounds identified
Anti-oxidant and Anticancerous Effect of Fomitopsis officinalis (Vill. ex Fr. Bond. et Sing) Mushroom on Hepatocellular Carcinoma Cells In Vitro through NF-kB Pathway
Altannavch N et al. • Anti-cancer agents in medicinal chemistry (2022)
This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.
- This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.
- To develop the impact of F. officinalis among natural products to treat/prevent oxidative stress disorders or cancers, further examinations of F. officinalis are needed to develop new natural drugs to treat cancer.
- However, this study assessed only one extract, Fo3-chloroformic, which has a significant impact against cancer cell lines.
Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content
Durgo K et al. • International journal of medicinal mushrooms (2013)
In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.
- To determine cytotoxic effects of single and blended mushroom extracts, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red assays were conducted using human small cell lung cancer, lung adenocarcinoma, colon cancer, and brain astrocytoma cancer cells.
- These results reveal that these extracts exhibit different cytotoxic effects on tumor cells originating from different tissues.
- In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.