Compare Supplements

Side-by-side comparison of 2 supplements

⚡

B-Complex

B-Complex (Methylated)

9/10 evidencehigh safety

View Full Details

🧬

Methylfolate

L-Methylfolate (5-MTHF)

9/10 evidencehigh safety

View Full Details

Evidence

Evidence Score

Tie9/10

Studies: 40+

Meta-analyses: 29

Avg Quality: 9.1/10

Evidence Score

Tie9/10

Studies: 40+

Meta-analyses: 13

Avg Quality: 8.6/10

Dosage & Timing

Dosage:

1 capsule daily (per label)

Best Time:

Morning with breakfast

Take with food

Form:

Methylated B-complex (methylcobalamin, methylfolate)

Dosage:

400-800mcg daily

Best Time:

Morning with or without food, Consistent daily timing

Can take on empty stomach

Form:

L-Methylfolate (5-MTHF)

What You'll Notice

⚡ More Energy70%

2-4 weeks

😊 Better Mood60%

4-8 weeks

💛 Bright Yellow Urine95%

Immediate

😊 Improved Mood70%

2-4 weeks

⚡ Increased Energy65%

1-3 weeks

❤️ Lower Homocysteine80%

4-8 weeks

Safety

high safety ratingTie

Contraindications:

Leber's disease (avoid high-dose B12)
Allergy to any B vitamin

Drug Interactions:

Levodopa
Methotrexate
Phenytoin

Side Effects:

NauseaBright yellow urineFlushing (high-dose niacin)

high safety ratingTie

Contraindications:

History of bipolar disorder (may trigger mania - start very low)
Seizure disorders (high doses)

Drug Interactions:

Methotrexate
Anti-seizure medications

Side Effects:

Anxiety/irritabilityInsomniaHeadache

Works Well With

Magnesiumcomplementary

Omega-3stacks-well

5-HTPenhances

B-Complex (Methylated)complementary

L-Methionineessential

Myo-Inositolcomplementary

Compare Supplements

B-Complex

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

Compare Supplements

B-Complex

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories