Head-to-head evidence comparison — which supplement is right for you?
Arginine and Potassium are closely matched across evidence, studies, and safety.
Amino Acid
Mineral
3-6g daily
30-60 minutes before exercise, Divided doses throughout the day for cardiovascular benefits
L-Arginine powder or capsules
99-500mg daily from supplements (food provides more)
With food to reduce GI upset, Spread throughout day, During/after exercise for athletes
Potassium Citrate or Potassium Gluconate
30-60 minutes
During exercise
2-4 weeks
Immediate
2-4 weeks
1-2 weeks
Long-term
With excess or kidney issues
Nutritional interventions for preventing and treating pressure ulcers
The Cochrane database of systematic reviews (2024) · Meta analysis · n=7920
Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low-certainty evidence).
Antioxidant supplementation for sickle cell disease
The Cochrane database of systematic reviews (2024) · Meta analysis · n=1609
Zinc versus placebo Zinc may not be better than placebo at reducing the frequency of crisis at six months (rate ratio 0.62, 95% CI 0.17 to 2.29; 1 study, 36 participants; low-certainty evidence).
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis
Nutrients (2023) · Meta analysis · n=2841
Glutamine was superior in decreasing tumor necrosis factor-α (MD -25.2; 95% CrI [-32.62, -17.95]), whereas combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85]).
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
Lancet (London, England) (2025) · Meta analysis · n=534
We found strong evidence that antidepressants differ markedly in their physiological effects, particularly for cardiometabolic parameters.
Spironolactone in patients on chronic haemodialysis at high risk of adverse cardiovascular outcomes (ALCHEMIST): a multicentre, double-blind, randomised, placebo-controlled trial and updated meta-analysis
Lancet (London, England) (2025) · Meta analysis · n=1442
In patients with kidney failure on haemodialysis and with high risk of adverse cardiovascular outcomes, spironolactone did not reduce the incidence of major cardiovascular events.
Potassium binders for chronic hyperkalaemia in people with chronic kidney disease
The Cochrane database of systematic reviews (2020) · Meta analysis · n=688
Patiromer or sodium zirconium cyclosilicate may make little or no difference to death (any cause) (4 studies, 688 participants: RR 0.69, 95% CI 0.11, 4.32; I2 = 0%; low certainty evidence) in CKD.
Both Arginine and Potassium are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Potassium has a higher relevance score (85 vs 70).
No known interactions between Arginine and Potassium have been documented in our database. However, always consult a healthcare provider before combining supplements.